New study reveals heart disease risk linked to PMOS

Media release: Tuesday 21 July 2026

New study shows strongest connection yet between ovarian syndrome and heart disease

The Heart Foundation has welcomed a major new study highlighting the strong link between polyendocrine metabolic ovarian syndrome (PMOS - formerly PCOS) and increased cardiovascular disease risk in women.

The large US study of more than 400,000 women, published today in The Lancet, found those with PMOS have more than a four times higher risk of cardiovascular disease, including heart attack, stroke and peripheral artery disease, compared to women without the condition, even after accounting for traditional risk factors.

Natalie Raffoul, Senior Manager Healthcare Programs and Clinical Strategy at the Heart Foundation, said the research reinforced that PMOS was a lifelong cardiometabolic disorder that could significantly affect heart health.

“Around one in eight women worldwide is affected by PMOS,” Ms Raffoul said.

“It is one of the most common endocrine conditions, yet its long-term cardiovascular implications are often under-recognised.

“These findings highlight the need for earlier identification of cardiovascular risk in women with PMOS and stronger focus on prevention, including support for healthy eating, physical activity, and ongoing monitoring.

“Increased awareness among both health professionals and patients is critical.”

Ms Raffoul said the new study added to a growing body of evidence that underscores the need for further research to better understand the drivers of risk and the most effective prevention strategies.

“Under the Heart Foundation’s 25-year vision, Health for Every Heart, we are committed to improving women’s heart health,” she said.

“Continuing to investigate connections between women’s health conditions and cardiovascular disease is one way we can ensure we achieve this goal.”