I am
heartfoundation.org.au|Helpline 13 11 12

Mitochondria and cardiovascular pathology

Dr Helena Viola, Institution: University of Western Australia

2017 Future Leader Fellowship

Years funded: 2018-2022


Hypertrophic cardiomyopathy affects 1:200 of the general population. It is the leading cause of sudden cardiac death in the young. However, no treatment exists that can prevent or reverse the disease.

Dr Helena Viola’s vision is to develop a translatable, early-intervention therapy for the prevention of hypertrophic cardiomyopathy and associated morbidity and mortality.

Dr Viola will lead a program that utilises specialist technologies in conjunction with key collaborations to identify the mechanisms of hypertrophic cardiomyopathy, and a novel early-intervention approach to prevent disease progression.

This will involve innovative use of hydrogel technology to develop an in vitro model of hypertrophic cardiomyopathy, and powerful techniques for assessing mitochondrial function Dr Viola has established over the past decade.

Dr Viola’s unique skillset encompassing biochemistry, electrophysiology, animal (in vitro through to in vivo) and human tissue studies facilitates her leadership of a multidisciplinary and translatable program of research.

Dr Viola’s research will:
  1. create knowledge by significantly advancing our understanding of mitochondrial function during both normal cardiac function and the development of hypertrophic cardiomyopathy,
  2. identify a unique, preventative approach for the treatment of hypertrophic cardiomyopathy and sudden cardiac death, and
  3. has therapeutic potential to significantly reduce morbidity and mortality of the costliest disease group in Australia

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Research Directory

Research Directory

Heart Health Check Toolkit

Heart Health Check Toolkit

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Apricot & pecan muffin bars

Apricot & pecan muffin bars

Apricot & pecan muffin bars

30 minutes
Serves 8

Fats, oils and heart health

Fats, oils and heart health

Fats, oils and heart health

Get the right balance of healthy fats in your diet ...

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Preventing heart disease starts with knowing your risk factors and making changes to live a healthier life. ...

Protein and heart health

Protein and heart health

Protein and heart health

What are the best sources of protein when it come to your heart health...

Heart stories

Heart stories

Heart stories

Stories of hope from Australian men and women fighting heart disease....

Breakfast bean and mushroom pizza

Breakfast bean and mushroom pizza

Breakfast bean and mushroom pizza

20 minutes
Serves 2

Women and heart disease

Women and heart disease

Women and heart disease

Every day, 22 women lose their lives to this condition....

Nutrition after a heart attack

Nutrition after a heart attack

Nutrition after a heart attack

Discover key information on heart-healthy eating and drinking....

Heart Bypass Surgery

Heart Bypass Surgery

Coronary bypass surgery is a common procedure that can dramatically improve the health of your heart. ...

Snack recipes

Snack recipes

Snack recipes

Search for healthy snack ideas...

Strategic Grants

Strategic Grants

Strategic Grants aim to generate innovative and collaborative research in the areas of identified knowledge gaps or those deemed to be priorities of the Heart Foundation. ...

Heart attack recovery – your first month

Heart attack recovery – your first month

Heart attack recovery – your first month

Explore the Heart Foundation’s guide on what to expect in the first month after your heart attack. ...

Smoking and tobacco regulation

Smoking and tobacco regulation

There are still more than 20,000 deaths caused by smoking every year....

Your heart medicines

Your heart medicines

Your heart medicines

Information about commonly prescribed heart medicines. ...

What is an arrhythmia?

What is an arrhythmia?

What is an arrhythmia?

Arrhythmia is a fault in the heart’s electrical system, which affects your heart’s pumping rhythm....

Q&A with Dr Lewan Parker

Q&A with Dr Lewan Parker

Q&A with Dr Lewan Parker

Identifying microvascular dysfunction as a novel mechanism of poor health in heart failure patients....

Nutrition Position Statements

Nutrition Position Statements

Nutrition Position Statements

The Heart Foundation’s food and nutrition position statements have been developed to keep you informed about our position on a range of nutrition issues relating to heart health. ...

Driving and travelling after a heart attack

Driving and travelling after a heart attack

Driving and travelling after a heart attack

Explore our guide for driving and heart attack recovery. ...

Long-term recovery after a heart attack

Long-term recovery after a heart attack

Long-term recovery after a heart attack

Information to help you adjust to what could be the 'new normal'...

Food and healthy eating during COVID-19

Food and healthy eating during COVID-19

Food and healthy eating during COVID-19

Healthy eating and COVID-19 FAQ...

Atrial Fibrillation (AF) clinical resources

Atrial Fibrillation (AF) clinical resources

Resources and clinical information for health professionals...

Heart Health Check Toolkit – Post-use evaluation survey

Heart Health Check Toolkit – Post-use evaluation survey

Absolute CVD risk clinical guidelines

Absolute CVD risk clinical guidelines

The Absolute Cardiovascular Disease Risk (CVD) Guidelines helps healthcare professionals identify, prevent and manage a person's risk of developing CVD. ...

What is heart failure?

What is heart failure?

What is heart failure?

Heart failure is a condition where your heart isn’t pumping as well as it should be....

Moroccan chickpea tagine

Moroccan chickpea tagine

25-40 minutes
Serves 4

Italian recipes

Italian recipes

Italian recipes

Find heart healthy Italian recipes....