Show me:
Show me:
Using ultrasound therapy to improve blood flow and save heart muscle during heart attack
heartfoundation.org.au|Helpline 13 11 12

Using ultrasound therapy to improve blood flow and save heart muscle during heart attack

Dr Prajith Jeyaprakash, Institution: University of Sydney

2021 PhD Scholarship

Years funded: 2022-2024

Current, standard-of-care for life-threatening heart attack (STEMI, ST elevation myocardial Infarction) uses stents to open large heart arteries blocked with blood clot. However, in half of patients with successful stent procedure, clot still blocks micro-vessels (MicroVascular Obstruction, MVO) causing poorer prognosis. To date, no intervention has successfully improved MVO. Sonothrombolysis (STL) is the repurposing of an existing diagnostic tool to treat STEMI. It uses high power ultrasound (sono) to break (lysis) micro-vessel clot (thrombo) whilst infusing a contrast agent. Previous animal studies and a recent single centre human study showed that STL salvaged more heart muscle by reducing MVO, however larger human trials are needed to prove safety and efficacy. Thus, the research team of Dr Jeyaprakash will perform a trial assessing STL in STEMI in 3 Australian hospitals. It is anticipate that STL will reduce muscle damage and improve outcomes. In future, STL can be delivered in ambulances to treat STEMI early, reduce heart muscle damage and ultimately save more lives.

You might also be interested in

The Heart Foundation Alumni Program

The Heart Foundation Alumni Program

The Heart Foundation Alumni Program

Stay connected with your research alumni community. ...

Research Directory

Research Directory

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

FACILITATING INTERNATIONAL CLINICAL TRIALS ...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Heart Foundation Research Award Recipients

Heart Foundation Research Award Recipients

Explore our research award recipients and projects...

Managing your funding

Managing your funding

Managing your funding

Resources to help manage your grant, scholarship or fellowship....

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Our research stories

Our research stories

Our research stories

We fund amazing researchers who have important stories to tell...

NSW Cardiovascular Research Network

NSW Cardiovascular Research Network

NSW Cardiovascular Research Network

Encouraging cardiovascular research excellence in NSW ...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Heart Health Check Toolkit

Heart Health Check Toolkit

Health Professional Tools

Health Professional Tools

Health Professional Tools

Guidelines, publications and support for the health professional community....

Together, we can change the future of heart disease

Together, we can change the future of heart disease

Together, we can change the future of heart disease

The power of your ongoing support can help save lives and keep more families together. Help us continue to fund promising heart research projects by donating today. ...

Time to book a Heart Health Check?

Time to book a Heart Health Check?

Time to book a Heart Health Check?

If you're 45 and over, or 30 and over if you're of Aboriginal or Torres Strait Islander descent, you should book your Heart Health Check today...

Beef recipes

Beef recipes

Beef recipes

Find heart healthy beef recipes....

Nutrition after a heart attack

Nutrition after a heart attack

Nutrition after a heart attack

Discover key information on heart-healthy eating and drinking....

Roast vegetable pasta

Roast vegetable pasta

30 minutes
Serves 6 (as a side)

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Preventing heart disease starts with knowing your risk factors and making changes to live a healthier life. ...

Dinner recipes

Dinner recipes

Dinner recipes

Search our heart healthy dinner recipes for tonights main meal...

Driving Best Practice CVD Prevention in a Post-COVID World

Driving Best Practice CVD Prevention in a Post-COVID World

Driving Best Practice CVD Prevention in a Post-COVID World

Hypertension clinical information and guidelines

Hypertension clinical information and guidelines

Clinical information for diagnosis and management of hypertension....

Feelings and emotions after a heart attack

Feelings and emotions after a heart attack

Feelings and emotions after a heart attack

This is a guide to how you might be feeling after a heart attack. ...

Women and heart disease

Women and heart disease

Women and heart disease

Information and resources for healthcare professionals....

Sodium and salt converter

Sodium and salt converter

Convert the sodium listed on food products into grams of salt or vice versa. ...

Lunch recipes

Lunch recipes

Lunch recipes

Search our lunch recipe ideas...

WEBINAR | Absolute CVD risk assessment practical update

WEBINAR | Absolute CVD risk assessment practical update

A multidisciplinary panel of experts discuss the practical application of absolute CVD risk assessment through Heart Health Checks....

Blood pressure and your heart

Blood pressure and your heart

Blood pressure and your heart

Understand blood pressure and how it can impact your heart health....

Getting active at school

Getting active at school

Getting active at school

Physical activity resources for school staff....

Heart attack recovery – your first month

Heart attack recovery – your first month

Heart attack recovery – your first month

Explore the Heart Foundation’s guide on what to expect in the first month after your heart attack. ...

Research Directory

Research Directory

Heart failure clinical resources

Heart failure clinical resources

Resources and clinical information for health professionals...

Cardiac Rehabilitation Advocacy

Cardiac Rehabilitation Advocacy

Q&A with Dr Umar Ali

Q&A with Dr Umar Ali

Q&A with Dr Umar Ali

Using simple blood and urine tests to detect coronary heart disease earlier....

Spontaneous Coronary Artery Dissection (SCAD)

Spontaneous Coronary Artery Dissection (SCAD)

Clinical information and links to SCAD resources....

Enhancing Cardiovascular Risk Prediction in Patients undergoing Liver Transplantation

Enhancing Cardiovascular Risk Prediction in Patients undergoing Liver Transplantation

Dr Anoop Koshy, Institution: The University of Melbourne...

The Heart Foundation Alumni Program

The Heart Foundation Alumni Program

The Heart Foundation Alumni Program

Stay connected with your research alumni community. ...

Nutrition Resources for Patients

Nutrition Resources for Patients

Nutrition Resources for Patients

Resources to help people follow a heart healthy eating pattern in their daily lives. ...

Italian fish parcels

Italian fish parcels

Italian fish parcels

20 minutes
Serves 4

Heart Foundation Walking

Heart Foundation Walking

Heart Foundation Walking

Learn more about Heart Foundation Walking and find your local walking group....

What is heart disease?

What is heart disease?

What is heart disease?

Heart disease is the broad term for conditions that affect the structure and function of the heart muscle. ...