Your heartHealthy livingFor professionalsResearchHow you can helpAbout us
Professor Claudia Nold, 2023 Vanguard Grant

Stopping inflammation to prevent early life heart disease

Research directory


Stopping inflammation to prevent early life heart disease

Professor Claudia Nold, Monash University

2023 Vanguard Grant - Two Year

Years funded: 2024 - 2025

Every year, preterm birth exposes 15 million infants worldwide (WHO), and ~26,000 infants in Australia, to serious early life diseases of heart and lung such as bronchopulmonary dysplasia (BPD), pulmonary hypertension associated with BPD (BPD-PH) and patent ductus arteriosus (PDA). Short- and long-term health issues arising from these diseases pose a serious socioeconomic burden. Importantly, the lack of safe and reliable therapies makes neonatal cardiovascular diseases an area of urgent unmet medical need. Inflammation, and specifically the potent inflammatory mediator IL-1, is now recognised as a key culprit promoting early life illness. IL-1Ra, the natural protein that blocks IL-1, has been safely used to treat many diseases for decades. Our clinical trial investigates whether IL-1Ra can protect preterm babies from BPD, BPD-PH and PDA. It is the first to offer preterm infants an anti-inflammatory treatment specifically tailored to address the disease-causing mediator, thereby offering these young patients a brighter outlook on life.

Last updated12 March 2024