Dr Lana McClements

New treatments for preeclampsia

Dr Lana McClements, University of Technology Sydney

2022 Future Leader Fellowship - Level 1

Years funded: 2023-2026

Preeclampsia is a dangerous pregnancy disorder characterised by the new onset of hypertension and organ damage. In Australia, preeclampsia affects 15,000+ women every year, placing a vast financial burden on health services (~100M per annum) due to high hospitalisation rates and neonatal care. Long-term morbidity post-preeclampsia is also increased in both mothers and their offspring. Despite this, there is no cure for preeclampsia.

This research program aims to develop and translate new and personalised treatments for preeclampsia by targeting the novel protein, FK506-binding protein like (FKBPL), which has an important role in the pathogenesis of preeclampsia. I plan to investigate a number of treatments in reliable preclinical models of preeclampsia and in 3D bioprinted or organ-on-a-chip models of placenta.

These new FKBPL-based technologies will improve the lives of women and children affected by preeclampsia, preventing both short- and long-term complications and morbidity.