I am
heartfoundation.org.au|Helpline 13 11 12

Emerging drug targets for heart failure

Dr Kate Weeks, Institution: Baker Heart and Diabetes Institute

2019 Future Leader Fellowship

Years funded: 2020-2023


Heart failure is a common endpoint for numerous cardiovascular diseases, including hypertension, coronary artery disease and type 2 diabetes. Approximately 50% of patients with heart failure die within 5 years of diagnosis, a mortality rate that is worse than that of many cancers. There is a clear need for new or improved therapies for the treatment of heart failure. This relies on a deeper understanding of the molecular and cellular mechanisms that contribute to the development of heart failure.

Phosphatases are a family of proteins that are emerging as promising drug targets for the treatment of cardiovascular diseases and other conditions. Phospatases are essential for many biological processes, and do not work properly in the failing heart. Understanding how phosphatases function in the healthy heart, and what goes wrong during heart failure, may lead to the development of new drugs to improve outcome in patients. This project will investigate the function of a phosphatase known as B55α-PP2A. Specifically, it will determine the role of B55α-PP2A in regulating abnormal heart enlargement during the development of heart failure.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Give with Heart Day

Give with Heart Day

Give with Heart Day

Landmarks around Australia to turn red in support of the Heart Foundation’s Give with Heart Day...

Heart Health Check Toolkit

Heart Health Check Toolkit

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Give with Heart Day

Give with Heart Day

Give with Heart Day

Donate to Give with Heart Day by September 15 and every dollar you donate will be doubled*...

Research Directory

Research Directory

Support for young adults: Online events

Support for young adults: Online events

Support for young adults: Online events

Check back in for the latest updates on Supporting Young Heart events...

Baking recipes

Baking recipes

Baking recipes

Find heart healthy baking recipes ...

Templates integrated in Best Practice software

Templates integrated in Best Practice software

Popular Heart Health Check templates – CVD risk assessment and management plan – are directly accessible from within Bp Premier ...

Supporting local Councils in South Australia

Supporting local Councils in South Australia

Supporting local Councils in South Australia

Resources to help support your council region to be healthy, connected and safe....

Loaded veggie shepherds pie

Loaded veggie shepherds pie

Loaded veggie shepherds pie

1 hour
Serves Serves 4 (as a main meal)

Mexican spice blend

Mexican spice blend

Mexican spice blend

Meatloaf

Meatloaf

40-50 minutes
Serves 6

Sit less, move more

Sit less, move more

Sit less, move more

You may be surprised to know that on average, adults sit for nine hours a day....

Relationships and sex after a heart attack

Relationships and sex after a heart attack

Relationships and sex after a heart attack

Explore some useful things to know about intimacy after a heart attack....

End of Financial Year Tax Receipt

End of Financial Year Tax Receipt

End of Financial Year Tax Receipt

Looking to claim your donations in your tax return this financial year?...

Being a carer for a heart attack patient

Being a carer for a heart attack patient

Being a carer for a heart attack patient

Your role as a carer for a heart attack patient is an important one – explore some useful things to know....

Atrial fibrillation resources for patients

Atrial fibrillation resources for patients

Driving and travelling after a heart attack

Driving and travelling after a heart attack

Driving and travelling after a heart attack

Explore our guide for driving and heart attack recovery. ...

What is heart failure?

What is heart failure?

What is heart failure?

Heart failure is a condition where your heart isn’t pumping as well as it should be....

What is coronary heart disease?

What is coronary heart disease?

What is coronary heart disease?

Coronary heart disease (CHD) or coronary artery disease occurs when a coronary artery clogs and narrows because of a buildup of plaque....

Exercises to do at home

Exercises to do at home

Exercises to do at home

All you need to know about keeping active during COVID-19....

Why are you playing this game? It’s putting your heart at risk.

Why are you playing this game? It’s putting your heart at risk.

Why are you playing this game? It’s putting your heart at risk.

The game is “hide and seek”. You play it without even realising. The shock is that when you play this game, you could be placing your heart health at risk....

Get your family moving

Get your family moving

Get your family moving

Get your kids active and set them up for healthier habits into adulthood....

Research connect newsletter

Research connect newsletter

Research connect newsletter

The Research Connect Newsletter provides monthly updates on the Heart Foundation Research Program....

Sodium and salt converter

Sodium and salt converter

Convert the sodium listed on food products into grams of salt or vice versa. ...

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

FACILITATING INTERNATIONAL CLINICAL TRIALS ...

Kids recipes

Kids recipes

Kids recipes

Find heart healthy kids recipes...

Q&A with Dr James Nadel

Q&A with Dr James Nadel

Q&A with Dr James Nadel

The role of inflammation in the development, identification and treatment of unstable blood vessel plaque...

Breakfast tacos

Breakfast tacos

Breakfast tacos

5 minutes
Serves 1