I am
heartfoundation.org.au|Helpline 13 11 12

Emerging drug targets for heart failure

Dr Kate Weeks, Institution: Baker Heart and Diabetes Institute

2019 Future Leader Fellowship

Years funded: 2020-2023


Heart failure is a common endpoint for numerous cardiovascular diseases, including hypertension, coronary artery disease and type 2 diabetes. Approximately 50% of patients with heart failure die within 5 years of diagnosis, a mortality rate that is worse than that of many cancers. There is a clear need for new or improved therapies for the treatment of heart failure. This relies on a deeper understanding of the molecular and cellular mechanisms that contribute to the development of heart failure.

Phosphatases are a family of proteins that are emerging as promising drug targets for the treatment of cardiovascular diseases and other conditions. Phospatases are essential for many biological processes, and do not work properly in the failing heart. Understanding how phosphatases function in the healthy heart, and what goes wrong during heart failure, may lead to the development of new drugs to improve outcome in patients. This project will investigate the function of a phosphatase known as B55α-PP2A. Specifically, it will determine the role of B55α-PP2A in regulating abnormal heart enlargement during the development of heart failure.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Heart Age Calculator

Heart Age Calculator

Heart Age Calculator

Could you be at risk of heart disease? Get your estimated heart age now....

Heart Health Check Toolkit

Heart Health Check Toolkit

Environment, climate change and heart health

Environment, climate change and heart health

Environment, climate change and heart health

Information on how air pollution, heatwaves and bushfires can impact heart health, and what you can do to look after yourself. ...

Beef recipes

Beef recipes

Beef recipes

Find heart healthy beef recipes....

Smoking and tobacco regulation

Smoking and tobacco regulation

There are still more than 20,000 deaths caused by smoking every year....

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Projects aimed at improving the heart health of Aboriginal and Torres Strait Islander peoples ...

What is heart disease?

What is heart disease?

What is heart disease?

Heart disease is the broad term for conditions that affect the structure and function of the heart muscle. ...

Salmon Tikka Parcels with Rice Salad

Salmon Tikka Parcels with Rice Salad

Salmon Tikka Parcels with Rice Salad

15 minutes
Serves 2

Heart-healthy baking spices up Christmas as keen Aussies celebrate post-lockdowns

Heart-healthy baking spices up Christmas as keen Aussies celebrate post-lockdowns

Heart-healthy baking spices up Christmas as keen Aussies celebrate post-lockdowns

Media release - 24 November 2021...

Moroccan chickpea tagine

Moroccan chickpea tagine

25-40 minutes
Serves 4

Lamb recipes

Lamb recipes

Lamb recipes

Find heart healthy lamb recipes....

WEBINAR | Lipids in the limelight: clinical update on screening and management

WEBINAR | Lipids in the limelight: clinical update on screening and management

Finding her voice: Sophie Nester’s heart story

Finding her voice: Sophie Nester’s heart story

Sophie Nester was born with a heart condition and a form of spina bifida. She had three open heart surgeries before she turned five. Now 26, Sophie is a disability support worker in Bendigo, Victoria....

Sweet potato breakfast hash

Sweet potato breakfast hash

Sweet potato breakfast hash

15 minutes
Serves 2

Absolute CVD risk clinical guidelines

Absolute CVD risk clinical guidelines

The Absolute Cardiovascular Disease Risk (CVD) Guidelines helps healthcare professionals identify, prevent and manage a person's risk of developing CVD. ...

Norm discovered he was at risk of a major heart attack just in the nick of time

Norm discovered he was at risk of a major heart attack just in the nick of time

Norm discovered he was at risk of a major heart attack just in the nick of time

Norm didn’t worry too much about his cholesterol problem – until an angiogram revealed he had an 80 per cent blockage in a major heart artery. ...

Being a carer for a heart attack patient

Being a carer for a heart attack patient

Being a carer for a heart attack patient

Your role as a carer for a heart attack patient is an important one – explore some useful things to know....

Roast chicken with onion, cherry tomato and pine nut stuffing

Roast chicken with onion, cherry tomato and pine nut stuffing

1 hour 50 minutes
Serves 6

2022 Vanguard Grants

2022 Vanguard Grants

Dairy and your heart health

Dairy and your heart health

Dairy and your heart health

Not all dairy products are equal. Discover different types of dairy foods and their impact on heart health....

Aboriginal heart health

Aboriginal heart health

Aboriginal heart health

Visit the St Vincents Hospital NSW and Heart Foundation Aboriginal heart health website for more information...

Romesco Sauce

Romesco Sauce

Romesco Sauce

Serves Makes 350g | (Serves 8 – about 2 tablespoons - 44g)

For professionals: Online education and training

For professionals: Online education and training

Online courses for health professionals focused on improving cardiovascular care. ...

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

Resources for providing best practice cardiovascular care for Aboriginal and Torres Strait Islander peoples....

Long-term recovery after a heart attack

Long-term recovery after a heart attack

Long-term recovery after a heart attack

Information to help you adjust to what could be the 'new normal'...

Remember a loved one with a tribute

Remember a loved one with a tribute

Remember a loved one with a tribute

Honour the life of a loved one with a donation to the Heart Foundation. Your donation offers hope for Australian hearts....

Vegetarian recipes

Vegetarian recipes

Vegetarian recipes

Search through our vegetarian recipes...

Clinical guidelines and position statements

Clinical guidelines and position statements

Clinical guidelines and position statements

We have developed a range of resources for you to use as part of routine care. ...

Research shows if you have gum disease, you’re twice as likely to have heart disease.

Research shows if you have gum disease, you’re twice as likely to have heart disease.

Research shows if you have gum disease, you’re twice as likely to have heart disease.

Know your risk: Family history and heart disease 

Know your risk: Family history and heart disease 

Know your risk: Family history and heart disease 

A family history of heart disease could mean you are at greater risk....