Cardiovascular disease remains the leading cause of death worldwide. New therapies are required to address this major unmet need. Lipids (molecules such as fats) are a major component of cell membranes including heart muscle cells. Recent studies have shown that lipids are altered in various pathologies, such as cardiovascular disease. Plasmalogens are a specific type of lipid that are enriched in the heart. Previous studies demonstrate that plasmalogen levels were reduced in a variety of disease settings such as atherosclerosis, and a dietary supplementation strategy conferred benefit against these disease types.
The major aims of Dr Yow Keat Tham's research project is to:
Expected outcomes: Dietary supplementation will increase plasmalogen levels in the heart and confer benefit against heart failure.
Last updated28 March 2022