I am
heartfoundation.org.au|Helpline 13 11 12

Cardiac matrix modulation after myocardial infarction

Dr Tejas Deshmukh, Institution: University of Sydney

2020 Health Professional Scholarship

Years funded: 2021-2023


Cardiovascular disease is a leading cause of death in Australia, with myocardial infarction (MI) and ischaemic heart disease being the major culprits. Although revascularisation (artery-opening) strategies over the last 3 decades have had a significant impact on early mortality, incremental benefits have plateaued. For these reasons, morbidity from chronic heart failure (HF) is increasing. The current treatment paradigm is to slow adverse cardiac remodelling (chronic HF stage) and to treat end-stage HF with heart transplantation. This is not a long-term solution. If we can shift the treatment paradigm towards regenerating injured tissue and fundamentally changing the cardiac scar that results after injury (coupled with quality measures for preventative care) enormous health care cost savings and decreased morbidity and mortality will result.

We have previously shown that recombinant human Platelet Derived Growth Factor (rhPDGF) can improve the heart function of both mice and pigs after induced heart attack. Before this promising therapy can be considered for clinical trials, further mechanistic details need to be elucidated. This will impact both early phase clinical trial design and be hypothesis generating for future regenerative therapies. The first part of the project will investigate the molecular and cellular changes that rhPDGF has on the infarcted heart. This will use novel and cutting-edge tools including high dimensional flow cytometry, mass cytometry and tensor diffusion imaging on cardiac MRI. The second part focuses on detailing the impact of scar homogeneity (by rhPDGF) on cardiac conduction, re-entrant circuits and ventricular arrhythmias. Outcomes of this project include expedited progression of this promising therapy, from the laboratory into the clinic where thousands of heart failure patients could one day benefit.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Heart Health Check Toolkit

Heart Health Check Toolkit

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Research Directory

Research Directory

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

FACILITATING INTERNATIONAL CLINICAL TRIALS ...

Cheesy Mexican vegetable pie

Cheesy Mexican vegetable pie

Cheesy Mexican vegetable pie

1 hour
Serves 4

Raffles & Lotteries

Raffles & Lotteries

Raffles & Lotteries

Give yourself a chance to win $20,000 while helping the Heart Foundation to raise essential funds for heart research....

Heart Foundation Research Award Recipients

Heart Foundation Research Award Recipients

Explore our research award recipients and projects...

Supporting Young Hearts Program

Supporting Young Hearts Program

Information and resources for health professionals who are treating patients between 18 - 40 years of age....

Kids recipes

Kids recipes

Kids recipes

Find heart healthy kids recipes...

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Projects aimed at improving the heart health of Aboriginal and Torres Strait Islander peoples ...

Feelings and emotions after a heart attack

Feelings and emotions after a heart attack

Feelings and emotions after a heart attack

This is a guide to how you might be feeling after a heart attack. ...

Endorsement of externally developed clinical resources

Endorsement of externally developed clinical resources

Finding her voice: Sophie Nester’s heart story

Finding her voice: Sophie Nester’s heart story

Sophie Nester was born with a heart condition and a form of spina bifida. She had three open heart surgeries before she turned five. Now 26, Sophie is a disability support worker in Bendigo, Victoria....

Atrial fibrillation resources for patients

Atrial fibrillation resources for patients

What is an arrhythmia?

What is an arrhythmia?

What is an arrhythmia?

Arrhythmia is a fault in the heart’s electrical system, which affects your heart’s pumping rhythm....

Smart Heart Guidelines App

Smart Heart Guidelines App

Access to Australian heart disease guidelines is now free at your fingertips...

For professionals: Aboriginal and Torres Strait Islander peoples identification training

For professionals: Aboriginal and Torres Strait Islander peoples identification training

Asking the Question of Origin course helps with identification of Aboriginal and Torres Strait Islander patients, in line with standard practice.  ...

How can I beat the barriers and get active for a healthy heart?

How can I beat the barriers and get active for a healthy heart?

How can I beat the barriers and get active for a healthy heart?

Philanthropic investments

Philanthropic investments

Philanthropic investments

Making philanthropic investments through the Heart Foundation can transform Australians’ health. ...

Staying active for better heart health

Staying active for better heart health

Staying active for better heart health

Moving more every day is one of the best habits you can have....

Research connect newsletter

Research connect newsletter

Research connect newsletter

The Research Connect Newsletter provides monthly updates on the Heart Foundation Research Program....

Create your fundraiser at Do it for Heart

Create your fundraiser at Do it for Heart

Create your fundraiser at Do it for Heart

Become a Heart Foundation fundraiser, do it for heart and make a real difference to your community....

Mighty mango smoothie

Mighty mango smoothie

Mighty mango smoothie

What is heart disease?

What is heart disease?

What is heart disease?

Heart disease is the broad term for conditions that affect the structure and function of the heart muscle. ...

Physical activity after a heart attack

Physical activity after a heart attack

Physical activity after a heart attack

Discover what you need to know about being active after a heart attack....

Strategic Grants

Strategic Grants

Strategic Grants aim to generate innovative and collaborative research in the areas of identified knowledge gaps or those deemed to be priorities of the Heart Foundation. ...

For Professionals: Coronary artery calcium scoring

For Professionals: Coronary artery calcium scoring

The National Heart Foundation of Australia Position Statement: Coronary artery calcium scoring for the primary prevention of cardiovascular disease in Australia.¹...

Resources for healthcare professionals

Resources for healthcare professionals

Resources for healthcare professionals

We have developed a range of resources for you to use as part of routine care. ...

Heart Week

Heart Week

Heart Week

May 3 – 9, 2021...