I am
heartfoundation.org.au|Helpline 13 11 12

A stroke vaccine

Professor Michael Good, Institution: Griffith University

2017 Stroke Prevention Grant

Years funded: 2019-2023


Rheumatic heart disease (RHD) affects 30 million people worldwide and is responsible for the loss
of over 350,000 lives per year with over 100,000 of these lives lost due to RHD-related stroke.
These are both embolic and haemorrhagic strokes. Australia’s Aboriginal and Torres Strait Islander
populations suffer the highest rates of RHD in the world with 3.2% in those aged 35-44 years
suffering from the disease. RHD only ever follows an infection with group A streptococcus (GAS)
and as such a vaccine to prevent streptococcal infection will prevent RHD–related strokes. We
have developed two candidate vaccines to prevent streptococcal infection – one to prevent skin
infection (impetigo and cellulitis) and the other to prevent tonsillitis. Infection in both sites can lead
to RHD and stroke. The vaccines cover all strains of GAS. The skin vaccine (IMVax) has already
been given to human volunteers in a pilot single dose study and shown to be safe and
immunogenic. The tonsillitis vaccine (MUCOVax) has not yet been administered to human
volunteers. Both vaccines are highly efficacious in pre-clinical models. Funding from this grant will
enable us to produce and test these vaccines in human volunteers and to then test the efficacy of
the vaccines using an NHMRC-funded facility where we can experimentally infect healthy adult
volunteers with streptococcus. If successful, these vaccines have the potential to dramatically
reduce the incidence of RHD-related strokes.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Heart Health Check Toolkit

Heart Health Check Toolkit

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Research Directory

Research Directory

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Smoking and your heart

Smoking and your heart

Smoking and your heart

Understand how smoking can impact your heart health. ...

What is heart disease?

What is heart disease?

What is heart disease?

Heart disease is the broad term for conditions that affect the structure and function of the heart muscle. ...

Benefits of physical activity for your heart

Benefits of physical activity for your heart

Benefits of physical activity for your heart

Physical activity and exercise can do wonders for your physical and mental health....

What is heart failure?

What is heart failure?

What is heart failure?

Heart failure is a condition where your heart isn’t pumping as well as it should be....

Fats, oils and heart health

Fats, oils and heart health

Fats, oils and heart health

Get the right balance of healthy fats in your diet ...

Endorsement of externally developed clinical resources

Endorsement of externally developed clinical resources

Dinner recipes

Dinner recipes

Dinner recipes

Search our heart healthy dinner recipes for tonights main meal...

Healthy eating to protect your heart

Healthy eating to protect your heart

Healthy eating to protect your heart

What does a heart-friendly diet look like?...

Heart Foundation recipes

Heart Foundation recipes

Heart Foundation recipes

Check out our recipe categories to find your next heart healthy meal....

Create your fundraiser at Do it for Heart

Create your fundraiser at Do it for Heart

Create your fundraiser at Do it for Heart

Become a Heart Foundation fundraiser, do it for heart and make a real difference to your community....

Q&A with Dr Louise Segan

Q&A with Dr Louise Segan

Q&A with Dr Louise Segan

Optimal treatment of atrial fibrillation in people with cardiac dysfunction and scarring of the heart ...

Apricot & pecan muffin bars

Apricot & pecan muffin bars

Apricot & pecan muffin bars

30 minutes
Serves 8

The HEART Pitch – a research competition by NSW CVRN

The HEART Pitch – a research competition by NSW CVRN

Live event on Friday 17 September 2021 – get your elevator pitch ready for the NSW CVRN Rising Stars 3-Minute Research Competition....

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

Resources for providing best practice cardiovascular care for Aboriginal and Torres Strait Islander peoples....

Research connect newsletter

Research connect newsletter

Research connect newsletter

The Research Connect Newsletter provides monthly updates on the Heart Foundation Research Program....

Cardiovascular disease (CVD) risk assessment and management

Cardiovascular disease (CVD) risk assessment and management

Absolute CVD risk assessment is an integrated approach that estimates the cumulative risk of multiple risk factors to predict a heart attack or stroke event in the next five years....

Help others in need through a gift in your Will

Help others in need through a gift in your Will

Help others in need through a gift in your Will

Ian “did not hesitate” to leave 100% of his estate to the Heart Foundation....

Healthy chicken fajitas

Healthy chicken fajitas

20 minutes
Serves 4

Breakfast recipes

Breakfast recipes

Breakfast recipes

Heart healthy breakfasts to start your day right...

Leaving a gift in your Will: A lasting legacy

Leaving a gift in your Will: A lasting legacy

Leaving a gift in your Will: A lasting legacy

One of the most powerful ways to help support a future without heart disease is to include a gift to the Heart Foundation in your Will...

Heart attack recovery – your first month

Heart attack recovery – your first month

Heart attack recovery – your first month

Explore the Heart Foundation’s guide on what to expect in the first month after your heart attack. ...

Kylie defied the heart attack stereotypes

Kylie defied the heart attack stereotypes

Kylie defied the heart attack stereotypes

Cardiac rehabilitation was a turning point for Kylie and essential to her heart failure recovery....

Heart conditions in women

Heart conditions in women

Heart conditions in women

Like men, women can be diagnosed with a range of heart conditions....

Heart failure clinical resources

Heart failure clinical resources

Resources and clinical information for health professionals...

Primary aldosteronism – a neglected cause of high blood pressure

Primary aldosteronism – a neglected cause of high blood pressure

Primary aldosteronism – a neglected cause of high blood pressure

Physical activity after a heart attack

Physical activity after a heart attack

Physical activity after a heart attack

Discover what you need to know about being active after a heart attack....