I am
heartfoundation.org.au|Helpline 13 11 12

A stroke vaccine

Professor Michael Good, Institution: Griffith University

2017 Stroke Prevention Grant

Years funded: 2019-2023


Rheumatic heart disease (RHD) affects 30 million people worldwide and is responsible for the loss
of over 350,000 lives per year with over 100,000 of these lives lost due to RHD-related stroke.
These are both embolic and haemorrhagic strokes. Australia’s Aboriginal and Torres Strait Islander
populations suffer the highest rates of RHD in the world with 3.2% in those aged 35-44 years
suffering from the disease. RHD only ever follows an infection with group A streptococcus (GAS)
and as such a vaccine to prevent streptococcal infection will prevent RHD–related strokes. We
have developed two candidate vaccines to prevent streptococcal infection – one to prevent skin
infection (impetigo and cellulitis) and the other to prevent tonsillitis. Infection in both sites can lead
to RHD and stroke. The vaccines cover all strains of GAS. The skin vaccine (IMVax) has already
been given to human volunteers in a pilot single dose study and shown to be safe and
immunogenic. The tonsillitis vaccine (MUCOVax) has not yet been administered to human
volunteers. Both vaccines are highly efficacious in pre-clinical models. Funding from this grant will
enable us to produce and test these vaccines in human volunteers and to then test the efficacy of
the vaccines using an NHMRC-funded facility where we can experimentally infect healthy adult
volunteers with streptococcus. If successful, these vaccines have the potential to dramatically
reduce the incidence of RHD-related strokes.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Heart Age Calculator

Heart Age Calculator

Heart Age Calculator

Could you be at risk of heart disease? Get your estimated heart age now....

Environment, climate change and heart health

Environment, climate change and heart health

Environment, climate change and heart health

Information on how air pollution, heatwaves and bushfires can impact heart health, and what you can do to look after yourself. ...

Heart Health Check Toolkit

Heart Health Check Toolkit

What is an arrhythmia?

What is an arrhythmia?

What is an arrhythmia?

Arrhythmia is a fault in the heart’s electrical system, which affects your heart’s pumping rhythm....

Atrial Fibrillation (AF) clinical resources

Atrial Fibrillation (AF) clinical resources

Resources and clinical information for health professionals...

Join Kate in making a difference to future generations

Join Kate in making a difference to future generations

Join Kate in making a difference to future generations

Kate wanted to find a way she could make a difference to future generations...

Cardiovascular disease risk factors and heart attack warning signs in women

Cardiovascular disease risk factors and heart attack warning signs in women

Cardiovascular disease risk factors and heart attack warning signs in women

Information for healthcare professionals and the public on cardiovascular disease risk factors and warning signs affecting women. ...

Heart procedures and devices

Heart procedures and devices

Heart procedures and devices

If you have a heart condition, your doctor may recommend different treatments, including procedures or devices. ...

Clinical resources: Coronary heart disease and mental health

Clinical resources: Coronary heart disease and mental health

The prevalence of depression is high in patients with coronary heart disease (CHD)....

Endorsement of externally developed clinical resources

Endorsement of externally developed clinical resources

COVID-19 info & FAQs

COVID-19 info & FAQs

COVID-19 info & FAQs

Information and FAQs about COVID-19 and heart disease....

For professionals: Online education and training

For professionals: Online education and training

Online courses for health professionals focused on improving cardiovascular care. ...

Q&A with Dr James Nadel

Q&A with Dr James Nadel

Q&A with Dr James Nadel

The role of inflammation in the development, identification and treatment of unstable blood vessel plaque...

What is heart failure?

What is heart failure?

What is heart failure?

Heart failure is a condition where your heart isn’t pumping as well as it should be....

What is heart valve disease?

What is heart valve disease?

What is heart valve disease?

Heart valve disease means that your heart valve or valves don't open or close properly....

Automated Implantable Cardioverter Defibrillator (ICD or AICD)

Automated Implantable Cardioverter Defibrillator (ICD or AICD)

This is a device inserted into your chest to return abnormal heart rhythms to normal using electrical impulses. ...

Dessert recipes

Dessert recipes

Dessert recipes

Find heart healthy dessert recipes....

How to keep your heart healthy habits rolling all year round

How to keep your heart healthy habits rolling all year round

How to keep your heart healthy habits rolling all year round

Personal Walking Plan

Personal Walking Plan

Personal Walking Plan

Feel healthier and happier in six weeks with a free Personal Walking Plan...

Coronary Artery Calcium Scoring

Coronary Artery Calcium Scoring

A coronary artery calcium score can be used following a Heart Health Check to estimate your risk of heart attack....

2020 Strategic Grant Recipients

2020 Strategic Grant Recipients

Q&A with Dr Jennifer Browne

Q&A with Dr Jennifer Browne

Food and Nutrition Policy for First Nations peoples – translating evidence into action...

Matilda signs up for Jump Rope just one month after open-heart surgery

Matilda signs up for Jump Rope just one month after open-heart surgery

Matilda signs up for Jump Rope just one month after open-heart surgery

Media Release - 26 June 2020...

Atrial fibrillation resources for patients

Atrial fibrillation resources for patients

Nutrition Evidence Summaries and Reviews

Nutrition Evidence Summaries and Reviews

Nutrition Evidence Summaries and Reviews

Support for young adults: Online events

Support for young adults: Online events

Support for young adults: Online events

Check back in for the latest updates on Supporting Young Heart events...

What is coronary heart disease?

What is coronary heart disease?

What is coronary heart disease?

Coronary heart disease (CHD) or coronary artery disease occurs when a coronary artery clogs and narrows because of a buildup of plaque....

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

FACILITATING INTERNATIONAL CLINICAL TRIALS ...

Baking recipes

Baking recipes

Baking recipes

Find heart healthy baking recipes ...

Heart Foundation recipes

Heart Foundation recipes

Heart Foundation recipes

Check out our recipe categories to find your next heart healthy meal....