I am
heartfoundation.org.au|Helpline 13 11 12

A Novel Anti-Inflammatory Approach to Treat Hypertension

Dr Chengxue Helena Qin, Institution: Monash University

2019 Vanguard Grant

Years funded: 2020-2022


Hypertension is the major risk factor for many cardiovascular diseases, and its incidence is predicted to continue to grow, thus developing novel pharmacological therapeutic approaches are essential to address the shortcomings of current therapies. Despite current knowledge that the immune system plays an important role in hypertension disease progression and end-organ damage, this is one therapeutic avenue that reminds to be explored. Thus, targeting receptor family integral to the inflammatory response, such as formyl peptide receptors (FPRs), may offer a new therapeutic approach to attenuate hypertension and the associated inflammatory state.

The applicant has identified a small-molecule FPR activator (Cmpd17b) that provides superior cardio-protection than the conventional activator, providing new insights on drug discovery strategy for cardiovascular disease. This paradigm-shifting discovery has been patented, and published in highly prestigious scientific journal. In addition, this work has also attracted significant media attention, and led to the recent establishment of a spin-off start-up biotech company (Limulus Therapeutics Pty Ltd

In this proposal, we will evaluate the capacity of our prototype small molecule (Cmpd17b) to improve blood vessel function and to prevent vascular re-modelling (scaring) in hypertension. Experiments will extend from cell based studies to well validated pre-clinical models of hypertension. The project will test the hypothesis that our prototype drug candidate will improve vascular function and protect against vascular injury in hypertension. We will examine the ability of FPR activator to lower blood pressure, and limit consequential blood vessel inflammation and re-modelling. The proposed studies will provide critical insight into the therapeutic potential of biased FPR agonists. We anticipate that this study will ultimately facilitate development of exciting new ways to treat hypertension, that affects 300,000 Australians.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Environment, climate change and heart health

Environment, climate change and heart health

Environment, climate change and heart health

Information on how air pollution, heatwaves and bushfires can impact heart health, and what you can do to look after yourself. ...

Heart Health Check Toolkit

Heart Health Check Toolkit

Heart Age Calculator

Heart Age Calculator

Heart Age Calculator

Could you be at risk of heart disease? Get your estimated heart age now....

Pregnancy and heart disease

Pregnancy and heart disease

Information and resources for health professionals....

Heart Foundation recipes

Heart Foundation recipes

Heart Foundation recipes

Check out our recipe categories to find your next heart healthy meal....

Mexican vegetarian pizza

Mexican vegetarian pizza

Mexican vegetarian pizza

10 minutes
Serves 2 (1 pizza per serve)

Heart procedures and devices

Heart procedures and devices

Heart procedures and devices

If you have a heart condition, your doctor may recommend different treatments, including procedures or devices. ...

Create your fundraiser at Do it for Heart

Create your fundraiser at Do it for Heart

Create your fundraiser at Do it for Heart

Become a Heart Foundation fundraiser, do it for heart and make a real difference to your community....

Australian Heart Maps

Australian Heart Maps

Australian Heart Maps

Our Heart Maps allow you to take a closer look at heart disease indicators across Australia....

For professionals: Heart failure tools and resources

For professionals: Heart failure tools and resources

Resources for healthcare professionals on the management of patients with heart failure ...

Roast vegetable pasta

Roast vegetable pasta

30 minutes
Serves 6 (as a side)

Lunch recipes

Lunch recipes

Lunch recipes

Search our lunch recipe ideas...

Tasty recipes to start the day | Breakfast Recipe Booklet

Tasty recipes to start the day | Breakfast Recipe Booklet

Tasty recipes to start the day | Breakfast Recipe Booklet

Have an easy and delicious start to your day. Get your free copy now....

Aiming high after a stroke

Aiming high after a stroke

Aiming high after a stroke

Sami Kennedy-Sim is an Olympic freestyle skier specialising in Ski Cross. ...

Benefits of physical activity for your heart

Benefits of physical activity for your heart

Benefits of physical activity for your heart

Physical activity and exercise can do wonders for your physical and mental health....

Heart stories

Heart stories

Heart stories

Stories of hope from Australian men and women fighting heart disease....

24-hour Blood Pressure Monitoring

24-hour Blood Pressure Monitoring

24-hour Blood Pressure Monitoring

Blood pressure monitoring at home using a 24-hour blood pressure monitor test....

Beef Burgers

Beef Burgers

Beef Burgers

10 minutes
Serves 2

Physical activity after a heart attack

Physical activity after a heart attack

Physical activity after a heart attack

Discover what you need to know about being active after a heart attack....

Absolute CVD risk assessment resources

Absolute CVD risk assessment resources

Resources and clinical information for health professionals...

Atrial fibrillation resources for patients

Atrial fibrillation resources for patients

Breakfast recipes

Breakfast recipes

Breakfast recipes

Heart healthy breakfasts to start your day right...

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

For Professionals: Aboriginal and Torres Strait Islander peoples information and resources

Resources for providing best practice cardiovascular care for Aboriginal and Torres Strait Islander peoples....

Our corporate partners

Our corporate partners

Our corporate partners

We value the support of all of our corporate partners....

Asian recipes

Asian recipes

Asian recipes

Find heart healthy Asian recipes....

Personal Walking Plan

Personal Walking Plan

Personal Walking Plan

Feel healthier and happier in six weeks with a free Personal Walking Plan...

2022 Collaboration and Exchange Award

2022 Collaboration and Exchange Award

2022 PhD Scholarship

2022 PhD Scholarship

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

2022 Postdoctoral Fellowship

2022 Postdoctoral Fellowship

The Postdoctoral Fellowship aims to identify the best and brightest (recent) PhD graduates, give them a boost to their research career and enhance their ability to attract and secure future funding....