I am
heartfoundation.org.au|Helpline 13 11 12

A new way to keep heart attack survivors healthy

Professor Kerry-Anne Rye, Institution: University of New South Wales

2020 Vanguard Grant

Years funded: 2021-2023


Heart attacks occur when a major artery is blocked by a blood clot. Heart attack survivors often have another heart attack within 5 years, progress to heart failure, and are up to six-times more likely to die of heart disease than a healthy person of comparable age. Current treatment options for reducing these adverse outcomes include preventing blood clots with anti-coagulants, lowering plasma LDL or “bad” cholesterol (LDL-C) levels with a statin, and decreasing blood pressure. Weight loss, stopping smoking, increasing physical activity and dietary improvements are also important, but compliance is frequently problematic.

However, LDL-C levels are often not sufficiently reduced in heart attack survivors, drugs that inhibit blood clot formation can increase the risk of bleeding, and blood pressure lowering drugs are useful only in patients with high blood pressure. These shortcomings highlight a major, unmet need for new therapeutic approaches to treat heart attack survivors. A potential strategy for achieving this goal is to reduce heart damage by inhibiting tissue inflammation and oxidation.

ApoA-I, the main protein in high density lipoproteins (HDLs), or “good” cholesterol, inhibits tissue inflammation and oxidation. However, levels of the inflammatory enzyme myeloperoxidase (MPO), which oxidises apoA-I and impairs its anti-inflammatory functions also increase after a heart attack. MPO additionally drives cardiovascular disease by oxidising LDLs, and impairing blood vessel function.

We have developed a clinically-viable peptide, D6PV, that mimics the anti-inflammatory properties of apoA-I. We also have access to a new class of potent MPO inhibitors, 2-thioxanthines, that protect proteins and peptides from oxidation by MPO. This project asks whether D6PV reduces inflammation after a heart attack, and whether this benefit is amplified by using D6PV with an MPO inhibitor. If successful, this project will deliver a new treatment regimen for heart attack survivors.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Heart Age Calculator

Heart Age Calculator

Heart Age Calculator

Could you be at risk of heart disease? Get your estimated heart age now....

Heart Health Check Toolkit

Heart Health Check Toolkit

Environment, climate change and heart health

Environment, climate change and heart health

Environment, climate change and heart health

Information on how air pollution, heatwaves and bushfires can impact heart health, and what you can do to look after yourself. ...

Roast vegetable pasta

Roast vegetable pasta

30 minutes
Serves 6 (as a side)

Salad recipes

Salad recipes

Salad recipes

Search through our tasty salad recipes...

Lipid management clinical information and resources

Lipid management clinical information and resources

Lipid management resources for health professionals...

Pregnancy and heart disease

Pregnancy and heart disease

Information and resources for health professionals....

For professionals: Cardiovascular disease risk assessment for Aboriginal and Torres Strait Islander peoples 

For professionals: Cardiovascular disease risk assessment for Aboriginal and Torres Strait Islander peoples 

Recommendations for assessing Cardiovascular disease (CVD) risk in Aboriginal and Torres Strait Islander peoples ...

Italian fish parcels

Italian fish parcels

Italian fish parcels

20 minutes
Serves 2

Aboriginal and Torres Strait Islander peoples: Heart health information and resources

Aboriginal and Torres Strait Islander peoples: Heart health information and resources

Aboriginal and Torres Strait Islander peoples: Heart health information and resources

Heart disease can occur 10 to 20 years earlier among Aboriginal and Torres Strait Islander peoples and can lead to long-term health problems. ...

Returning to work after a heart attack

Returning to work after a heart attack

Returning to work after a heart attack

Discover how to plan for your return to work....

Heart-healthy baking spices up Christmas as keen Aussies celebrate post-lockdowns

Heart-healthy baking spices up Christmas as keen Aussies celebrate post-lockdowns

Heart-healthy baking spices up Christmas as keen Aussies celebrate post-lockdowns

Media release - 24 November 2021...

Keeping your heart healthy

Keeping your heart healthy

Keeping your heart healthy

Keeping your heart healthy is something you can work on every day. ...

What is heart disease?

What is heart disease?

What is heart disease?

Heart disease is the broad term for conditions that affect the structure and function of the heart muscle. ...

Donation receipts

Donation receipts

Donation receipts

Due to end of financial year and the ongoing lockdowns in several states, we are currently experiencing some delays in processing and receipting of donations....

Encouraging cardiovascular research excellence in South Australia

Encouraging cardiovascular research excellence in South Australia

Encouraging cardiovascular research excellence in South Australia

Heart Bypass Surgery

Heart Bypass Surgery

Coronary bypass surgery is a common procedure that can dramatically improve the health of your heart. ...

Q&A with Professor Levon Khachigian

Q&A with Professor Levon Khachigian

Q&A with Professor Levon Khachigian

Developing a new medicine for inflammatory cardiovascular disease...

Chicken and avocado banh mi

Chicken and avocado banh mi

Chicken and avocado banh mi

15 minutes + 30 minutes chilling
Serves 2

Beef recipes

Beef recipes

Beef recipes

Find heart healthy beef recipes....

Food and healthy eating during COVID-19

Food and healthy eating during COVID-19

Food and healthy eating during COVID-19

Healthy eating and COVID-19 FAQ...

Our research stories

Our research stories

Our research stories

We fund amazing researchers who have important stories to tell...

Reading food labels

Reading food labels

Reading food labels

Nutrition information panels and ingredients lists are a good way of comparing similar foods so you can choose the healthiest option....

Blueprint for an active Australia 

Blueprint for an active Australia 

Blueprint for an active Australia 

The Blueprint for an active Australia provides evidence-based actions to help address physical inactivity....

WEBINAR | The future of CVD risk assessment

WEBINAR | The future of CVD risk assessment

WEBINAR | The future of CVD risk assessment

Should population-based CVD risk assessment models make way for individualised risk prediction techniques?...

Workplace giving for employees

Workplace giving for employees

Workplace giving for employees

Your employer’s workplace giving program makes it easy to setup regular, tax-deductible donations from your pre-tax income. ...

Heart Foundation delivers $17.2 million for cutting-edge heart research in a challenging year

Heart Foundation delivers $17.2 million for cutting-edge heart research in a challenging year

Heart Foundation delivers $17.2 million for cutting-edge heart research in a challenging year

Media Release 20 October 2020...

Easy chicken nasi goreng

Easy chicken nasi goreng

Easy chicken nasi goreng

10 minutes
Serves 4

What is coronary heart disease?

What is coronary heart disease?

What is coronary heart disease?

Coronary heart disease (CHD) or coronary artery disease occurs when a coronary artery clogs and narrows because of a buildup of plaque....

Heart failure clinical resources

Heart failure clinical resources

Resources and clinical information for health professionals...