I am
heartfoundation.org.au|Helpline 13 11 12

A new drug delivery platform called Nano-Ghosts loaded with a protective gene for the failing heart

Professor Julie McMullen, Institution: Baker Heart and Diabetes Institute

2019 Vanguard Grant

Years funded: 2020-2022


New treatments to protect the heart after a heart attack are urgently needed. In this proposal we will load a novel drug delivery system called “Nano-Ghosts” with drugs targeting a protective pathway in the heart (referred to as the PI3K pathway below). This project has the potential to lead to a new cardiac therapy for the human failing heart.  

Aim 1: To manufacture and assess Nano-Ghosts with payloads (drugs) targeting the PI3K pathway in vitro and in healthy adult mice.

Aim 2: To assess the most promising PI3K-targeted Nano-Ghost formulations in a setting of ischemia-reperfusion (heart disease model).

Outcomes: The development of Nano-Ghosts targeting the diseased heart with drugs acting on the PI3K pathway. Innovation: A first-of-a-kind cardiac therapy based on Nano-Ghosts combined with the potent therapeutic activity of PI3K-based drugs. Impact: A new therapy to minimise infarct size and subsequently prevent or greatly reduce infarct-induced heart failure.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Research Directory

Research Directory

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Heart Health Check Toolkit

Heart Health Check Toolkit

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Asian (Chilli, soy and sesame) dressing

Asian (Chilli, soy and sesame) dressing

Asian (Chilli, soy and sesame) dressing

Mighty mango smoothie

Mighty mango smoothie

Mighty mango smoothie

COVID-19 info & FAQs

COVID-19 info & FAQs

COVID-19 info & FAQs

Information and FAQs about COVID-19 and heart disease....

Stay informed about COVID-19

Stay informed about COVID-19

Stay informed about COVID-19

If you have heart disease, you are more vulnerable to severe complications....

Research connect newsletter

Research connect newsletter

Research connect newsletter

The Research Connect Newsletter provides monthly updates on the Heart Foundation Research Program....

Absolute CVD risk clinical guidelines

Absolute CVD risk clinical guidelines

The Absolute Cardiovascular Disease Risk (CVD) Guidelines helps healthcare professionals identify, prevent and manage a person's risk of developing CVD. ...

WEBINAR | The future of CVD risk assessment

WEBINAR | The future of CVD risk assessment

WEBINAR | The future of CVD risk assessment

Should population-based CVD risk assessment models make way for individualised risk prediction techniques?...

For professionals: Heart failure tools and resources

For professionals: Heart failure tools and resources

Resources for healthcare professionals on the management of patients with heart failure ...

Tahini tofu dressing

Tahini tofu dressing

Tahini tofu dressing

Health Professional Ambassador Program

Health Professional Ambassador Program

Health Professional Ambassador Program

Would you like to improve the cardiovascular health of your patients?...

What is heart valve disease?

What is heart valve disease?

What is heart valve disease?

Heart valve disease means that your heart valve or valves don't open or close properly....

Baking recipes

Baking recipes

Baking recipes

Find heart healthy baking recipes ...

Moroccan chickpea tagine

Moroccan chickpea tagine

25-40 minutes
Serves 4

Aboriginal and Torres Strait Islander peoples: Heart health information and resources

Aboriginal and Torres Strait Islander peoples: Heart health information and resources

Aboriginal and Torres Strait Islander peoples: Heart health information and resources

Heart disease can occur 10 to 20 years earlier among Aboriginal and Torres Strait Islander peoples and can lead to long-term health problems. ...

Aboriginal and Torres Strait Islander peoples: Lower your risk of heart disease

Aboriginal and Torres Strait Islander peoples: Lower your risk of heart disease

Aboriginal and Torres Strait Islander peoples: Lower your risk of heart disease

Support and resources to help you stay healthy and reduce risk of heart disease. ...

Heart attack recovery – your first month

Heart attack recovery – your first month

Heart attack recovery – your first month

Explore the Heart Foundation’s guide on what to expect in the first month after your heart attack. ...

Get your family moving

Get your family moving

Get your family moving

Get your kids active and set them up for healthier habits into adulthood....

How can I beat the barriers and get active for a healthy heart?

How can I beat the barriers and get active for a healthy heart?

How can I beat the barriers and get active for a healthy heart?

Sodium and salt converter

Sodium and salt converter

Convert the sodium listed on food products into grams of salt or vice versa. ...

Loaded veggie shepherds pie

Loaded veggie shepherds pie

Loaded veggie shepherds pie

1 hour
Serves Serves 4 (as a main meal)

Atrial fibrillation resources for patients

Atrial fibrillation resources for patients

Breakfast recipes

Breakfast recipes

Breakfast recipes

Heart healthy breakfasts to start your day right...

Getting active at school

Getting active at school

Getting active at school

Physical activity resources for school staff....

Heart Bypass Surgery

Heart Bypass Surgery

Coronary bypass surgery is a common procedure that can dramatically improve the health of your heart. ...

Fundraise to save Australian hearts

Fundraise to save Australian hearts

Fundraise to save Australian hearts

Join our community of fundraisers who are committed to taking action to fight heart disease....

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Projects aimed at improving the heart health of Aboriginal and Torres Strait Islander peoples ...