Dr Melanie White

Institute: University of Sydney
Category:
Current Project

How the diabetic heart is ‘primed’ to fail following cardiovascular stress

Patients with pre-existing type 2 diabetes have significantly impaired clinical outcomes following a cardiovascular event (e.g. ischemia), in comparison to otherwise ‘healthy’ individuals.

We suggest that the type 2 diabetes heart undergoes molecular adaptations that subsequently increase cell death or reduce pro-survival mechanisms upon ischemia.

]We have also observed elevated controlled cell death…

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