Dr Lauren May

Institute: Monash University
Current Project

G protein-coupled receptor context-specific biased agonism to treat heart disease

Heart attack and secondary heart failure remain significant health burdens. 
Stimulation of adenosine G protein-coupled receptors (ARs) located on heart cells confers potent cardioprotection, improving acute and longer-term heart function following a heart attack. 

Unfortunately, the transition of AR drugs into the clinic has thus far failed due to: 
  i) a lack of on-target potency…

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