Dr Lauren May
G protein-coupled receptor context-specific biased agonism to treat heart disease
Heart attack and secondary heart failure remain significant health burdens.
Stimulation of adenosine G protein-coupled receptors (ARs) located on heart cells confers potent cardioprotection, improving acute and longer-term heart function following a heart attack.
Unfortunately, the transition of AR drugs into the clinic has thus far failed due to:
i) a lack of on-target potency…