Optimising the Treatment of Coronary Artery Disease

Years funded:
2017 - 2021

With an overall aim of improving the understanding, survival and quality of life of patients with coronary artery disease, Professor Ravinay Bhindi’s research program spans across the molecular laboratory to the cardiac catheterisation laboratory using state-of-the-art intravascular imaging with Optical Coherence Tomography (OCT) and intravascular physiology using pressure wire. 

Professor Bhindi's research encompasses two interrelated themes: 

1. Improving clinical accuracy of intracoronary physiology assessments in patients presenting in Atrial Fibrillation (AF) with symptomatic coronary artery disease and angiographically intermediate stenosis. By applying comprehensive physiology assessment and by building on an established international collaboration, Professor Bhindi will assess the effect of AF on the validity of standard blood-flow measures during cardiac catheterisation. 

2. Improving understanding of Saphenous Vein Graft (SVG) failure following heart bypass surgery. By integrating and applying Molecular and Imaging techniques (OCT and Intravascular Ultrasound) which have been previously developed in Professor Bhindi’s research with clinical practice, he will comprehensively characterise critical elements of SVG failure. This will improve understanding of the SVG atherosclerosis and ‘plaque instability’ leading to improved design and application of therapeutic agents.

Researcher Profile

Professor Ravinay Bhindi

Institute: University of Sydney
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