Maximizing Stroke Treatment Outcome After Reperfusion

Years funded:
2018 - 2020

Stroke is the most frequent cause of permanent disability in adults and a major cause of death in Australia. 

Opening blocked blood vessels to restore blood flow to brain cells starved of oxygen is the main aim of currently available treatment. However, even after completely re-opening the vessels, some living brain cells still die despite receiving blood flow for reasons not completely understood, while some brain cells have unexplained new bleeding and swelling. 

These events have major impacts on how effective treatments are which directly affects patients’ long-term recovery and outcome. 

This research is directly focused on understanding these processes by using advanced state-of-the-art MRI and CT technologies to analyse how human brain cells die and recover after regaining blood flow. 
The research will also study what may be causing dangerous bleeding after re-opening blood vessels and how this can be prevented from further injuring the vulnerable brain. 

Ultimately, understanding these unanswered fundamental questions will be major step in the progress of discovering new treatments to help brain cells become more resilient and have a better recovery following a stroke. 
The ability to predict and prevent bleeding complications after treatment may also substantially enhance the benefit patients receive from the currently available treatment. 

Overall, this will help stroke sufferers live with less disability and reduce the devastating disease burden.

Researcher Profile

Dr Felix Ng

Institute: University of Melbourne
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