How white blood cells develop in arteries during atherosclerosis

Years funded:
2015 - 2018

White blood cells (macrophages) play a key role in the development of plaque build-up and hardening of the arteries (atherosclerosis), which is the underlying cause of most heart attacks and strokes.

The origins of macrophages have long been thought to be from circulating blood cells called monocytes. However new discoveries show that there are actually stem cells (also known as progenitor or parent cells) for macrophages that exist within the outer lining of blood vessels. This project will study whether these local progenitor cells, called AMPCs, are a source of macrophages in atherosclerosis. If so, this could lead to new treatment approaches that target AMPCs to prevent or treat cardiovascular disease.

Researcher Profile

Dr Peter Psaltis

Institute: The University of Adelaide
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