Developing preventative and therapeutic strategies in HFPEF

Years funded:
2016 - 2018

Heart failure is one of the most common and most disabling forms of cardiovascular disease.

There are two forms; heart failure with reduced ejection fraction (HFREF), meaning the heart muscle cannot pump appropriately, and heart failure with preserved ejection fraction (HFPEF), a limitation in the heart's ability to relax and draw blood into the pumping chamber. Both make up about 50% of heart failure, with the second type increasing in frequency.

HFPEF often presents with shortness of breath, particularly with exercise. There are a multitude of medical and interventional therapies in existence for HFREF, and no proven effective therapies for HFPEF.

The aim of this project is to approach the disease from multiple angles; a careful review of the current literature available, several mechanistic studies to understand the underlying processes, and multiple preclinical and clinical trials to assess therapeutic options.

Researcher Profile

Dr Shane Nanayakkara

Institute: Baker Heart and Diabetes Institute
Learn More