Developing preventative and therapeutic strategies in HFPEF
- Years funded:
- 2016 - 2018
Heart failure is one of the most common and most disabling forms of cardiovascular disease.
There are two forms; heart failure with reduced ejection fraction (HFREF), meaning the heart muscle cannot pump appropriately, and heart failure with preserved ejection fraction (HFPEF), a limitation in the heart's ability to relax and draw blood into the pumping chamber. Both make up about 50% of heart failure, with the second type increasing in frequency.
HFPEF often presents with shortness of breath, particularly with exercise. There are a multitude of medical and interventional therapies in existence for HFREF, and no proven effective therapies for HFPEF.
The aim of this project is to approach the disease from multiple angles; a careful review of the current literature available, several mechanistic studies to understand the underlying processes, and multiple preclinical and clinical trials to assess therapeutic options.
Dr Shane Nanayakkara
|Institute:||Baker Heart and Diabetes Institute|