Clinical Utility and Feasibility of Point of Care CT-Derived Fractional Flow Reserve

Years funded:
2018 - 2019

Patients with suspected angina are commonly referred by cardiologists to undergo investigations to determine the presence of coronary artery disease (CAD) and its haemodynamic significance. 

The haemodynamic significance of a narrowing represents the degree to which coronary blood flow is impaired and is a strong predictor of adverse outcomes. 

CT coronary angiography (CTCA) is an established non–invasive method to diagnose CAD, however it is limited in its ability to determine its haemodynamic significance. 

The current gold standard for assessing haemodynamic significance is fractional flow reserve (FFR). This is performed during invasive coronary angiography using a pressure wire across a narrowing artery which allows investigators to determine the degree to which blood flow is impaired. 

FFR is well established in diagnosing the severity of CAD and guiding its treatment. CT Derived Fractional Flow Reserve (CT-FFR) is an emerging non-invasive method for determining FFR and the haemodynamic significance across a coronary artery narrowing detected on CTCA. 

Dr Abdul Ihdayhid’s previous work demonstrated that it is highly accurate compared to FFR. This technique is potentially practice changing as it allows CTCA to become a safe, convenient, non-invasive “one stop shop” investigation for diagnosis of CAD and assessment of its haemodynamic significance.

This study will assess the real-world feasibility of using CT-FFR in clinical practice and its potential at reducing unnecessary downstream invasive investigations.

Researcher Profile

Dr Abdul Ihdayhid

Institute: Monash University
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