Central Nervous System and Treatment for Chronic Kidney Disease

Years funded:
2017 - 2018

Deterioration of kidney function results in excessive stimulation of certain brain regions via increased nerve signalling from the diseased kidneys. These stimulated brain neurons constantly activate the sympathetic nervous system and can lead to damage of the heart, the blood vessels, and the kidneys themselves. 

Identifying the specific brain neurons that receive and process the signal from the kidney is therefore crucial to better understanding the mechanisms of the progression of cardiovascular disease related to kidney disease. Furthermore, blocking the nerve pathways between the kidney and the brain might be beneficial for the treatment of kidney disease and to prevent subsequent cardiovascular disease. 

Dr Yusuke Sata’s research is designed to identify the role of nerve pathways and specific brain regions responsible for chronic kidney disease by blocking renal nerve traffic in a kidney disease model. 

Dr Sata’s research will also investigate treatment effects of blocking the renal nerves in patients with chronic kidney disease by either a drug (moxonidine) or a catheter-based technique. 

Preliminary data suggest that the nerves connecting the kidney to the brain are particularly important in the regulation of continued sympathetic nerve activation. Therefore, interruption of nerve traffic may well be useful for the treatment of kidney disease.

Researcher Profile

Dr Yusuke Sata

Institute: Baker Heart and Diabetes Institute
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