Catheter ablation for persistent atrial fibrillation: A Multicenter randomised study (CAPLA)

Years funded:
2017 - 2019

Atrial fibrillation (AF) is the most common abnormal heart rhythm (arrhythmia) affecting the population which decreases quality of life and significantly increases health care costs.

In patients with paroxysmal AF, a minimally invasive procedure called radiofrequency catheter ablation (RFA) is the standard of care leading to excellent control.

This is associated with improved quality of life and decreased health care burden. However, the efficacy and outcomes of RFA in persistent AF (recurrent AF that is resistant to non invasive treatment) is suboptimal with standard RFA.

Previously,  a major trial has shown no difference with additional ablation but more recent evidence has shown that an additional step called posterior wall isolation (PWI) may improve longer term success of the procedure.

The results maybe comparable to those undergoing standard ablation for paroxysmal AF.

Hence we have designed this first international randomised multicenter trial comparing posterior wall isolation (PWI) to standard ablation in patients with persistent AF.

This trial is expected to show that addition of PWI to standard ablation will result in effective and sustained maintenance of regular rhythm in this patient population. Patients with persistent AF are most likely to benefit the from an effective intervention.

Researcher Profile

Dr Hariharan Sugumar

Institute: Baker Heart and Diabetes Institute
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