Can a simple blood test improve prediction of coronary disease?
- Years funded:
- 2017 - 2019
Coronary artery disease (CAD) develops when major blood vessels that supply the heart with blood, oxygen and nutrients become damaged or diseased. CAD typically develops over decades, so many people do not know they have it until it starts causing problems. It results in more Australian deaths than any other single cause but remains under diagnosed and undertreated. Early detection is key because there are a number of things we can do to treat CAD and prevent a heart-attack or death. Unfortunately, about half of people developing CAD are incorrectly considered unlikely to develop it, leading to a delay in diagnosis. Therefore, better tests are needed to diagnose CAD early.
Our research plan is to perform a simple, new blood test in a large number of patients who have symptoms due to confirmed CAD. We will compare blood levels of these patients to those without CAD. Our theory is that levels will be significantly increased only in those with CAD and that high levels will predict the risk of getting a heart-attack or dying.
If our theory is confirmed, this test may then be used to better predict those with CAD even before they develop symptoms. It will allow provision of more personalised risk assessment and prevention strategies which will likely reduce complications of CAD.
Our group has entensive experience conducting research in this specific area and hence we are well-placed to ensure the study is conducted in a thoughtful, ethical and time-efficient manner.
Dr Jay Ramchand
|Institute:||University of Melbourne|