I am
heartfoundation.org.au|Helpline 13 11 12

The Role of Myocardial Disease in Phenotypes of Cardiac Ageing

Dr Jonathan Sen, Institution: Baker Heart and Diabetes Institute

2019 Health Professional Scholarship

Years funded: 2020-2021


Cardiovascular disease (CVD) is the leading cause of death and disability in the world and has the greatest impact on patients over 65 years old. As the heart muscle (myocardium) weakens with advancing age, it is unable to provide enough blood to the bodys vital organs, leading to an increased risk of developing heart failure. Diagnostic and management strategies for CVD are currently extrapolated from clinical trials with sparse representation of the elderly. An understanding of how to control myocardial ageing is key to developing new strategies to improve the management of medical conditions common in the rapidly expanding ageing population for example, heart failure and aortic stenosis. Echocardiography (echo) is a clinically relevant and useful non-invasive tool for cardiac assessment. The direct relationship between echo parameters and myocardial ageing and how these correlate with clinical outcomes remains unclear.

Echo has the potential to improve early recognition of age-related cardiac-specific physiological changes and monitor responses to interventions. A large number of parameters are relevant to the echocardiographic examination, and these multi-dimensional data exceed the capability of standard analysis. Machine learning and big data analysis in health care is an emerging field that has the capability to identify associations in these datasets. This project aims to use big data and machine learning to integrate echo parameters, clinical and laboratory data to improve prognostication and risk assessment of the contributions of myocardial ageing to aortic stenosis and heart failure. The ultimate goal is to improve and enhance treatment of myocardial diseases by devising age-appropriate management guidelines.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Heart Health Check Toolkit

Heart Health Check Toolkit

Environment, climate change and heart health

Environment, climate change and heart health

Environment, climate change and heart health

Information on how air pollution, heatwaves and bushfires can impact heart health, and what you can do to look after yourself. ...

Heart Age Calculator

Heart Age Calculator

Heart Age Calculator

Could you be at risk of heart disease? Get your estimated heart age now....

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

Vegetarian recipes

Vegetarian recipes

Vegetarian recipes

Search through our vegetarian recipes...

Roast vegetable pasta

Roast vegetable pasta

30 minutes
Serves 6 (as a side)

Workplace giving for employees

Workplace giving for employees

Workplace giving for employees

Your employer’s workplace giving program makes it easy to setup regular, tax-deductible donations from your pre-tax income. ...

2022 Vanguard Grants

2022 Vanguard Grants

What is plant-based eating

What is plant-based eating

What is plant-based eating

Learn about plant-based eating and its impact on heart health ...

9 food and heart health myths, busted

9 food and heart health myths, busted

9 food and heart health myths, busted

Let’s dive into nine common food and health myths and the facts behind them....

How your heart works

How your heart works

How your heart works

Your heart is a muscle that pumps blood to all parts of your body. The blood gives your body the oxygen and nourishment it needs to work properly. ...

Permanent Pacemaker (PPM)

Permanent Pacemaker (PPM)

A small, battery-powered device that is fitted under the skin of your upper chest....

Absolute CVD risk clinical guidelines

Absolute CVD risk clinical guidelines

The Absolute Cardiovascular Disease Risk (CVD) Guidelines helps healthcare professionals identify, prevent and manage a person's risk of developing CVD. ...

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Projects aimed at improving the heart health of Aboriginal and Torres Strait Islander peoples ...

Aboriginal heart health

Aboriginal heart health

Aboriginal heart health

Visit the St Vincents Hospital NSW and Heart Foundation Aboriginal heart health website for more information...

Baking recipes

Baking recipes

Baking recipes

Find heart healthy baking recipes ...

Chicken and two-grain stuffed capsicums

Chicken and two-grain stuffed capsicums

Chicken and two-grain stuffed capsicums

10 - 12 minutes
Serves 4

Breakfast recipes

Breakfast recipes

Breakfast recipes

Heart healthy breakfasts to start your day right...

My health for life program

My health for life program

My health for life program

The Heart Foundation is a proud supporter of the Queensland My health for life program...

Jump Rope for Heart

Jump Rope for Heart

Jump Rope for Heart

Jump Rope for Heart teaches school children how to keep fit and healthy through skipping!...

Q&A with A/Prof Seana Gall

Q&A with A/Prof Seana Gall

Q&A with A/Prof Seana Gall

Improving the prevention and management of stroke...

What is FoodTrack?

What is FoodTrack?

What is FoodTrack?

FoodTrack supports the collection and monitoring of nutrition and product data for foods and beverages in Australian supermarkets. ...

The Heart Foundation Alumni Program

The Heart Foundation Alumni Program

The Heart Foundation Alumni Program

Stay connected with your research alumni community. ...

Mental health and heart disease

Mental health and heart disease

Mental health and heart disease

Having a mental health condition can have a negative impact on your heart health and increase your risk of heart disease....

Heart Foundation delivers $17.2 million for cutting-edge heart research in a challenging year

Heart Foundation delivers $17.2 million for cutting-edge heart research in a challenging year

Heart Foundation delivers $17.2 million for cutting-edge heart research in a challenging year

Media Release 20 October 2020...

Hypertension clinical information and guidelines

Hypertension clinical information and guidelines

Clinical information for diagnosis and management of hypertension....

Become a corporate partner

Become a corporate partner

Become a corporate partner

Partner with us to help us fight for Australian hearts....

Lipid management clinical information and resources

Lipid management clinical information and resources

Lipid management resources for health professionals...

What is a cardiac arrest?

What is a cardiac arrest?

What is a cardiac arrest?

With immediate help a cardiac arrest can be survived. Learn how to save a life....

Ranch burger bowls

Ranch burger bowls

Ranch burger bowls

20 minutes
Serves 4