I am
heartfoundation.org.au|Helpline 13 11 12

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Years funded: 2014-2020

Associate Professor Mark Parsons has made two recent advances that could bring about a global transformation in acute stroke care. The first is the use of advanced brain imaging to identify potentially salvageable brain tissue surrounding the event – the ischaemic penumbra. The second is the recent discovery in a Phase II trial that the new generation intravenous thrombolytic (blood clot-breaking) agent, tenecteplase, provides better outcomes clinically and in managing damage as blood flow returns to the affected area, when compared to the current standard blood clotbreaker, alteplase.

Tenecteplase versus alteplase for stroke thrombolysis evaluation (TASTE), conceived and led by Associate Professor Parsons, is a large Phase III randomised trial designed to generate practice-changing evidence by applying the advanced imaging treatment selection approach used in his recent positive Phase II trial. TASTE aims to confirm the superiority of tenecteplase over alteplase in a broader group of stroke patients who are eligible for acute thrombolytic treatment in the current time window (less than 4.5 hours after stroke onset).

TASTE will address crucial clinical and pathophysiologic questions in a much broader group of stroke patients eligible for acute thrombolytic therapy. A positive study result would be applicable to millions of people worldwide (including some 25% of the more than 30,000 Australians who present early with acute ischaemic stroke each year), and will undoubtedly directly translate into a major change in clinical practice.

This project is co-funded with National Stroke Foundation.

Researcher Profile:

Mark Parsons
Institute : University of Melbourne

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Give with Heart Day

Give with Heart Day

Give with Heart Day

Landmarks around Australia to turn red in support of the Heart Foundation’s Give with Heart Day...

Research Directory

Research Directory

Give with Heart Day

Give with Heart Day

Give with Heart Day

Donate to Give with Heart Day by September 15 and every dollar you donate will be doubled*...

Heart Health Check Toolkit

Heart Health Check Toolkit

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Dairy and your heart health

Dairy and your heart health

Dairy and your heart health

Not all dairy products are equal. Discover different types of dairy foods and their impact on heart health....

Heart Foundation Research Award Recipients

Heart Foundation Research Award Recipients

Explore our research award recipients and projects...

Heart failure clinical resources

Heart failure clinical resources

Resources and clinical information for health professionals...

Cardiac Rehabilitation for Health Professionals - Patient Resources

Cardiac Rehabilitation for Health Professionals - Patient Resources

Healthy chicken fajitas

Healthy chicken fajitas

20 minutes
Serves 4

Nutrition after a heart attack

Nutrition after a heart attack

Nutrition after a heart attack

Discover key information on heart-healthy eating and drinking....

Heart Foundation Walking

Heart Foundation Walking

Heart Foundation Walking

Learn more about Heart Foundation Walking and find your local walking group....

Italian recipes

Italian recipes

Italian recipes

Find heart healthy Italian recipes....

Driving Best Practice CVD Prevention in a Post-COVID World

Driving Best Practice CVD Prevention in a Post-COVID World

Driving Best Practice CVD Prevention in a Post-COVID World

Dessert recipes

Dessert recipes

Dessert recipes

Find heart healthy dessert recipes....

For Professionals: Coronary artery calcium scoring

For Professionals: Coronary artery calcium scoring

The National Heart Foundation of Australia Position Statement: Coronary artery calcium scoring for the primary prevention of cardiovascular disease in Australia.¹...

Kid-friendly lentil stew

Kid-friendly lentil stew

30 minutes
Serves 4

Hot oats – (base recipe)

Hot oats – (base recipe)

Hot oats – (base recipe)

10 minutes
Serves 2 (Makes 2 cups)

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Projects aimed at improving the heart health of Aboriginal and Torres Strait Islander peoples ...

Taking your medicines

Taking your medicines

Taking your medicines

There are many medicines that treat heart attack, angina, high blood pressure, high cholesterol and other heart conditions....

What is an arrhythmia?

What is an arrhythmia?

What is an arrhythmia?

Arrhythmia is a fault in the heart’s electrical system, which affects your heart’s pumping rhythm....

Heart attack recovery – quit smoking

Heart attack recovery – quit smoking

Heart attack recovery – quit smoking

Smoking is a major risk factor for heart disease. Get the facts on quitting and how it can help you recover. ...

Heart failure resources for patients

Heart failure resources for patients

Educate your patients on everything they need to know about heart failure and managing their condition ...

Trek for Australian Hearts

Trek for Australian Hearts

Trek for Australian Hearts

Join the Heart Foundation in South Australia for the journey of a lifetime, trekking the ancient Flinders Ranges to help save Australian hearts....

Cheesy Mexican vegetable pie

Cheesy Mexican vegetable pie

Cheesy Mexican vegetable pie

1 hour
Serves 4

Breakfast bean and mushroom pizza

Breakfast bean and mushroom pizza

Breakfast bean and mushroom pizza

20 minutes
Serves 2

Blood cholesterol

Blood cholesterol

Blood cholesterol

Keeping your blood cholesterol at a healthy level can help you reduce your risk of heart disease and other serious conditions. ...

Heart Foundation recipes

Heart Foundation recipes

Heart Foundation recipes

Check out our recipe categories to find your next heart healthy meal....

Research connect newsletter

Research connect newsletter

Research connect newsletter

The Research Connect Newsletter provides monthly updates on the Heart Foundation Research Program....