I am
heartfoundation.org.au|Helpline 13 11 12

Targeting platelets to break down blood clots - sex specific treatments

Dr Laura Bienvenu, Institution: Baker Heart and Diabetes Institute

2018 Postdoctoral Fellowship

Years funded: 2019-2021


My project aims to break down blood clots using targeted antibody-drug fusions. Thrombosis, the formation of blood clots within a vessel, is a leading cause of death in Australia. Using clot-busting drugs that are genetically fused to antibodies, we can break down blood clots by targeting activated platelets. These antibody-drug fusions can attach to clots, accumulate at the site of clot development and break them down.

We have previously shown that these targeted-drug can improve heart function after an induced heart attack. While these drugs have been proven successful for current therapy, their small molecular size hinders their use for long-term prophylactic approach.

In order to propose a paradigm changing use of our targeted-drug fusion for prophylaxis, I will improve the circulating half-life by increasing the size of targeted-drug, thereby allowing these treatments to be used prior to disease occurrence. One of the current problems in most experimental studies is the fact that they were investigated only in male mice. Men and women have different incidence and outcomes of cardiovascular disease related to thrombosis, such as stroke and myocardial infarction.

For this reason, sex-differences in cardiovascular disease has been gaining attention. The overall aim of this project is to generate new long circulating targeted-drugs, to assess treatment on blood clot formation and cardiac function after a heart attack, as well as to identify sex-specific differences.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Give with Heart Day

Give with Heart Day

Give with Heart Day

Landmarks around Australia to turn red in support of the Heart Foundation’s Give with Heart Day...

Research Directory

Research Directory

Give with Heart Day

Give with Heart Day

Give with Heart Day

Donate to Give with Heart Day by September 15 and every dollar you donate will be doubled*...

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Heart Health Check Toolkit

Heart Health Check Toolkit

Atrial Fibrillation (AF) clinical resources

Atrial Fibrillation (AF) clinical resources

Resources and clinical information for health professionals...

Clinical resources: Coronary heart disease and mental health

Clinical resources: Coronary heart disease and mental health

The prevalence of depression is high in patients with coronary heart disease (CHD)....

Support after a heart attack

Support after a heart attack

Support after a heart attack

Many different thoughts may go through your head after a heart attack and you may be presented with complicated medical info. Know where to get support. ...

Supporting Young Hearts

Supporting Young Hearts

Supporting Young Hearts

Advice from young people living with a heart condition....

Romesco Sauce

Romesco Sauce

Romesco Sauce

Serves Makes 350g | (Serves 8 – about 2 tablespoons - 44g)

Action Plans

Action Plans

Action Plans

Recovery is a long journey, so having a plan makes a huge difference. Using an action plan gives you a step-by-step guide to improving your lifestyle....

Mexican spice blend

Mexican spice blend

Mexican spice blend

Taking your medicines

Taking your medicines

Taking your medicines

There are many medicines that treat heart attack, angina, high blood pressure, high cholesterol and other heart conditions....

Italian veggie fritters with tomato salad

Italian veggie fritters with tomato salad

Italian veggie fritters with tomato salad

20 minutes
Serves Serves 4 (as a main meal)

Cheesy Mexican vegetable pie

Cheesy Mexican vegetable pie

Cheesy Mexican vegetable pie

1 hour
Serves 4

Women and heart disease

Women and heart disease

Women and heart disease

Every day, 22 women lose their lives to this condition....

Fundraise to save Australian hearts

Fundraise to save Australian hearts

Fundraise to save Australian hearts

Join our community of fundraisers who are committed to taking action to fight heart disease....

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

FACILITATING INTERNATIONAL CLINICAL TRIALS ...

Smoking and your heart

Smoking and your heart

Smoking and your heart

Understand how smoking can impact your heart health. ...

Hypertension clinical information and guidelines

Hypertension clinical information and guidelines

Clinical information for diagnosis and management of hypertension....

Dairy and your heart health

Dairy and your heart health

Dairy and your heart health

Not all dairy products are equal. Discover different types of dairy foods and their impact on heart health....

Absolute CVD risk charts

Absolute CVD risk charts

Absolute CVD risk charts provide a visual tool to calculate CVD risk for use in practice in Australia....

Personal Walking Plan

Personal Walking Plan

Personal Walking Plan

Feel healthier and happier in six weeks with a free Personal Walking Plan...

Strawberry fields oats

Strawberry fields oats

Strawberry fields oats

10 minutes
Serves 2

Heart Foundation reviews its operations in challenging financial environment

Heart Foundation reviews its operations in challenging financial environment

Heart Foundation reviews its operations in challenging financial environment

6 September 2021...

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Aboriginal and Torres Strait Islander peoples: Are you at risk of heart disease? 

Preventing heart disease starts with knowing your risk factors and making changes to live a healthier life. ...

Q&A with Dr Rachel Climie

Q&A with Dr Rachel Climie

Q&A with Dr Rachel Climie

Vascular ageing and cardiovascular disease in high-risk populations...

Heart Foundation supports Wollongong City Council’s draft 10-year cycling strategy

Heart Foundation supports Wollongong City Council’s draft 10-year cycling strategy

Heart Foundation supports Wollongong City Council’s draft 10-year cycling strategy

Media Release - 30 June 2020 ...

Women and heart disease

Women and heart disease

Women and heart disease

Information and resources for health professionals....