I am
heartfoundation.org.au|Helpline 13 11 12

Personalising the treatment of sleep apnoea

Associate Professor Bradley Edwards, Institution: Monash University

2016 Future Leader Fellowship

Years funded: 2017-2020


Obstructive sleep apnoea (OSA) is a common disorder in which the airway repeatedly closes throughout the night and has serious consequences for cardiovascular health. While the gold standard treatment (to wear a mask connected to a machine that blows air into your airway to prevent airway collapse) is highly effective, it is poorly tolerated by many. Mandibular advancement devices (MAD) and upper airway surgery (UAS) are the most common alternative treatments. Unfortunately, a significant number of patients referred for these treatments do not respond and suffer from residual OSA with its inherent cardiovascular sequelae. Furthermore, current clinical predictive tools are poor at identifying responders to UAS/MAD and there are no proven additional therapies to offer those patients failing UAS/MAD therapy.

This proposal aims to
  1. investigate the effect of UAS/MAD on the physiological processes underlying OSA and allow for the successful selection of patients for these therapies and
  2. determine if patients who fail to respond to UAS/MAD can be effectively ‘rescued’ with the addition of oxygen therapy.

The potential outcomes of this research are that it will enable an individualised and effective mechanism-based therapy approach for the many patients whose OSA currently remains untreated and at great risk of serious cardiovascular complications. Most importantly, the tools generated through this work will also be immediately translatable to clinical practice.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Research Directory

Research Directory

Heart Health Check Toolkit

Heart Health Check Toolkit

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Give with Heart Day

Give with Heart Day

Give with Heart Day

Landmarks around Australia to turn red in support of the Heart Foundation’s Give with Heart Day...

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Give with Heart Day

Give with Heart Day

Give with Heart Day

Donate to Give with Heart Day by September 15 and every dollar you donate will be doubled*...

Pregnancy and heart disease

Pregnancy and heart disease

Information and resources for health professionals....

Relationships and sex after a heart attack

Relationships and sex after a heart attack

Relationships and sex after a heart attack

Explore some useful things to know about intimacy after a heart attack....

Permanent Pacemaker (PPM)

Permanent Pacemaker (PPM)

A small, battery-powered device that is fitted under the skin of your upper chest....

Fruit and nut muesli

Fruit and nut muesli

Fruit and nut muesli

Heart Bypass Surgery

Heart Bypass Surgery

Coronary bypass surgery is a common procedure that can dramatically improve the health of your heart. ...

Q&A with Dr Lewan Parker

Q&A with Dr Lewan Parker

Q&A with Dr Lewan Parker

Identifying microvascular dysfunction as a novel mechanism of poor health in heart failure patients....

What is a cardiac arrest?

What is a cardiac arrest?

What is a cardiac arrest?

With immediate help a cardiac arrest can be survived. Learn how to save a life....

WEBINAR | Heart Health Checks: the critical role of the practice nurse

WEBINAR | Heart Health Checks: the critical role of the practice nurse

WEBINAR | Heart Health Checks: the critical role of the practice nurse

This webinar discusses the role of practice nurses in conducting heart health checks...

3 Minute Research Competition Terms & Conditions

3 Minute Research Competition Terms & Conditions

Sorting out your finances after a heart attack

Sorting out your finances after a heart attack

Sorting out your finances after a heart attack

Explore how to manage your financial concerns after a heart attack. ...

Heart Foundation reviews its operations in challenging financial environment

Heart Foundation reviews its operations in challenging financial environment

Heart Foundation reviews its operations in challenging financial environment

6 September 2021...

Physical activity resources

Physical activity resources

Physical activity resources

Resources for health professionals interested in physical activity....

What is cardiac rehab?

What is cardiac rehab?

What is cardiac rehab?

Cardiac rehab is proven to keep you out of hospital and reduce your risk of death from heart conditions....

Overcoming uncertainty: Bianca Beetham’s heart story

Overcoming uncertainty: Bianca Beetham’s heart story

Overcoming uncertainty: Bianca Beetham’s heart story

Bianca Beetham is 24 years old and lives in Sydney. She is currently waiting for her first open-heart surgery after being diagnosed with hypertrophic cardiomyopathy five years ago....

Heart attack medication

Heart attack medication

Heart attack medication

There are a number of medications you could be prescribed after a heart attack....

How your heart works

How your heart works

How your heart works

Your heart is a muscle that pumps blood to all parts of your body. The blood gives your body the oxygen and nourishment it needs to work properly. ...

Healthy chicken fajitas

Healthy chicken fajitas

20 minutes
Serves 4

Romesco Sauce

Romesco Sauce

Romesco Sauce

Serves Makes 350g | (Serves 8 – about 2 tablespoons - 44g)

Heart Foundation Recovery Support and Resources

Heart Foundation Recovery Support and Resources

Heart Foundation Recovery Support and Resources

Heart Foundation programs and resources to support your recovery....

Feelings and emotions after a heart attack

Feelings and emotions after a heart attack

Feelings and emotions after a heart attack

This is a guide to how you might be feeling after a heart attack. ...

About the Lighthouse Hospital Project

About the Lighthouse Hospital Project

Heart disease is the number one cause of death in Australia, but the burden of disease disproportionately affects Aboriginal and Torres Strait Islander peoples....

Cardiac Rehabilitation for Health Professionals - Patient Resources

Cardiac Rehabilitation for Health Professionals - Patient Resources

Hot oats – (base recipe)

Hot oats – (base recipe)

Hot oats – (base recipe)

10 minutes
Serves 2 (Makes 2 cups)

What is angina?

What is angina?

What is angina?

Angina is a type of chest pain or discomfort that’s a symptom of an underlying heart problem, usually coronary heart disease (CHD)....