I am
heartfoundation.org.au|Helpline 13 11 12

Personalising Antiplatelet Therapy in Left Ventricular Assist Device Supported Patients

Dr Kavitha Muthiah, Institution: Victor Chang Cardiac Research Institute

2017 Postdoctoral Fellowship

Years funded: 2018-2020


Some patients with severe heart failure require a mechanical heart pump known as left ventricular assist device to support them whilst waiting for a heart transplant.

Although this pump is good at treating heart failure symptoms such as breathlessness and fatigue, they are prone to forming clots within them which may stop the pump from working or lead to stroke. To minimise this risk, patients who are on the pump have to take blood thinning medications.

A normal heart beats rhythmically approximately 70 times a minute, hence generating a periodic pulse, but this mechanical pump generates continuous flow which may cause additional changes to the blood system and vessels.

The combination of blood thinning medications with changes to blood system and vessels due to the continuous flow causes bleeding, especially from the stomach and bowel.

The aim of this study is to correlate changes in the blood system and proteins involved in new blood vessel formation. We hope to use the information obtained to formulate an algorithm that will allow blood thinning medication use to be individualised and thereby minimise the combined risks of bleeding and blood clot formation in patients who require a left ventricular assist device in the future.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Environment, climate change and heart health

Environment, climate change and heart health

Environment, climate change and heart health

Information on how air pollution, heatwaves and bushfires can impact heart health, and what you can do to look after yourself. ...

Heart Age Calculator

Heart Age Calculator

Heart Age Calculator

Could you be at risk of heart disease? Get your estimated heart age now....

Heart Health Check Toolkit

Heart Health Check Toolkit

One pot green goodness pasta

One pot green goodness pasta

One pot green goodness pasta

15 minutes
Serves 4

Aiming high after a stroke

Aiming high after a stroke

Aiming high after a stroke

Sami Kennedy-Sim is an Olympic freestyle skier specialising in Ski Cross. ...

Finding a new purpose: Geoff Lester’s heart story

Finding a new purpose: Geoff Lester’s heart story

Finding a new purpose: Geoff Lester’s heart story

Dr Geoff Lester, 35, is training to be a cardiologist at Coffs Harbour Hospital. He has survived three high-risk open-heart surgeries and two strokes....

Italian veggie fritters with tomato salad

Italian veggie fritters with tomato salad

Italian veggie fritters with tomato salad

20 minutes
Serves 4 (as a main meal)

Our history

Our history

Our history

For more than 60 years the Heart Foundation has been helping improve heart health across the nation....

Remember a loved one with a tribute

Remember a loved one with a tribute

Remember a loved one with a tribute

Honour the life of a loved one with a donation to the Heart Foundation. Your donation offers hope for Australian hearts....

Atrial Fibrillation (AF) clinical resources

Atrial Fibrillation (AF) clinical resources

Resources and clinical information for health professionals...

Nutrition Position Statements

Nutrition Position Statements

Nutrition Position Statements

The Heart Foundation’s food and nutrition position statements have been developed to keep you informed about our position on a range of nutrition issues relating to heart health. ...

WEBINAR | The future of CVD risk assessment

WEBINAR | The future of CVD risk assessment

WEBINAR | The future of CVD risk assessment

Should population-based CVD risk assessment models make way for individualised risk prediction techniques?...

One pan honey mustard chicken

One pan honey mustard chicken

One pan honey mustard chicken

30 minutes
Serves 2

One pot green goodness pasta

One pot green goodness pasta

One pot green goodness pasta

15 minutes
Serves 2

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

GLOBAL CARDIOVASCULAR RESEARCH FUNDERS FORUM

FACILITATING INTERNATIONAL CLINICAL TRIALS ...

Aboriginal heart health

Aboriginal heart health

Aboriginal heart health

Visit the St Vincents Hospital NSW and Heart Foundation Aboriginal heart health website for more information...

Pumpkin falafel wraps

Pumpkin falafel wraps

Pumpkin falafel wraps

10 minutes
Serves Serves 4 (as a main meal)

Christmas recipes

Christmas recipes

Christmas recipes

Find heart healthy festive recipes. ...

What is a healthy body weight?

What is a healthy body weight?

What is a healthy body weight?

Find out what a healthy body weight is and the steps you can take to achieve it. ...

What is heart failure?

What is heart failure?

What is heart failure?

Heart failure is a condition where your heart isn’t pumping as well as it should be....

Action Plans

Action Plans

Action Plans

Recovery is a long journey, so having a plan makes a huge difference. Using an action plan gives you a step-by-step guide to improving your lifestyle....

Heart Bypass Surgery

Heart Bypass Surgery

Coronary bypass surgery is a common procedure that can dramatically improve the health of your heart. ...

Endorsement of externally developed clinical resources

Endorsement of externally developed clinical resources

Clinical Guidelines

Clinical Guidelines

Clinical Guidelines

Full list of clinical guidlines and references for CVD, heart failure, ACS, hypertension, atrial fibrillation, SCAD and RHD...

Chest x-ray for heart disease

Chest x-ray for heart disease

Chest x-ray for heart disease

This test can help your doctor determine if there is anything wrong with your heart....

Heart failure clinical resources

Heart failure clinical resources

Resources and clinical information for health professionals...

Baking recipes

Baking recipes

Baking recipes

Find heart healthy baking recipes ...

Heart Foundation reviews its operations in challenging financial environment

Heart Foundation reviews its operations in challenging financial environment

Heart Foundation reviews its operations in challenging financial environment

6 September 2021...

Q&A with Dr Dean Picone

Q&A with Dr Dean Picone

Q&A with Dr Dean Picone

Easy chicken nasi goreng

Easy chicken nasi goreng

Easy chicken nasi goreng

10 minutes
Serves 2