I am
heartfoundation.org.au|Helpline 13 11 12

Novel coagulation biomarkers in high-risk cardiovascular population

Dr Hui Yin Lim, Institution: University of Melbourne

2017 Health Professional Scholarship

Years funded: 2018-2021


While significant progress has been made in the treatment of cardiovascular disease (CVD), the ability to evaluate the risk of thrombosis has not been well elucidated and is limiting our capacity to develop and monitor new treatments.

Current available laboratory investigations only provide information about the time to the start of clotting, which accounts for only <5% of clot formation, without assessing the other crucial aspects of thrombosis including total clot formation, vessel wall function, platelet function as well as the role of genetic modulation of the thrombotic response.

New experimental global coagulations assays such as the calibrated automated thrombogram (CAT) calculates the thrombin generation (i.e. total clot formation) and provides a more accurate global assessment of coagulation.

This prospective study aims to improve our evaluation of clotting pathways in cardiovascular medicine through the use of global coagulation assay and novel coagulation biomarkers, as well as demonstrate the compensatory mechanism between the different arms of the Virchow’s triad in cardiovascular diseases.

The ability to evaluate these new biomarkers will also provide a holistic understanding of an individual's true clotting risk and will assist in prevention and monitoring of cardiovascular diseases.

This project is co-funded with NHMRC - National Health and Medical Research Council.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Heart Health Check Toolkit

Heart Health Check Toolkit

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Research Directory

Research Directory

Strawberry fields oats

Strawberry fields oats

Strawberry fields oats

10 minutes
Serves 2

Donate Monthly | Become a Regular Donor

Donate Monthly | Become a Regular Donor

Donate Monthly | Become a Regular Donor

Join the fight against heart disease....

Lamb recipes

Lamb recipes

Lamb recipes

Find heart healthy lamb recipes....

Q&A with Dr Susie Cartledge

Q&A with Dr Susie Cartledge

Q&A with Dr Susie Cartledge

Breaking down the silos - a pathway from acute hospital care to cardiac rehabilitation ...

Heart-healthy drinks

Heart-healthy drinks

Heart-healthy drinks

While water is clearly the most heart-healthy drink, there are other drinks that can be enjoyed in moderation. ...

3 Minute Research Competition Terms & Conditions

3 Minute Research Competition Terms & Conditions

What is an arrhythmia?

What is an arrhythmia?

What is an arrhythmia?

Arrhythmia is a fault in the heart’s electrical system, which affects your heart’s pumping rhythm....

Your heart is your most important tool

Your heart is your most important tool

Your heart is your most important tool

Men’s Health Week is the perfect time to think about your heart....

5 warning signs of a heart attack that you may not know

5 warning signs of a heart attack that you may not know

5 warning signs of a heart attack that you may not know

Aboriginal and Torres Strait Islander peoples: Lower your risk of heart disease

Aboriginal and Torres Strait Islander peoples: Lower your risk of heart disease

Aboriginal and Torres Strait Islander peoples: Lower your risk of heart disease

Support and resources to help you stay healthy and reduce risk of heart disease. ...

Leaving a gift in your Will: A lasting legacy

Leaving a gift in your Will: A lasting legacy

Leaving a gift in your Will: A lasting legacy

One of the most powerful ways to help support a future without heart disease is to include a gift to the Heart Foundation in your Will...

Q&A with Dr Nathan Palpant

Q&A with Dr Nathan Palpant

Q&A with Dr Nathan Palpant

Deadly spider venom offers hope to people having a heart attack...

Vegetarian lasagne

Vegetarian lasagne

Vegetarian lasagne

1 hour
Serves 6

How can I set and achieve goals to improve my heart health?

How can I set and achieve goals to improve my heart health?

How can I set and achieve goals to improve my heart health?

Question of the month blog...

Women and heart disease

Women and heart disease

Women and heart disease

Every day, 22 women lose their lives to this condition....

Heart procedures and devices

Heart procedures and devices

Heart procedures and devices

If you have a heart condition, your doctor may recommend treatment or procedures...

Learning to listen to your heart

Learning to listen to your heart

Learning to listen to your heart

Guest blog by Heart Foundation of Australia Group CEO, Adjunct Professor John G Kelly AM...

Ranch dressing

Ranch dressing

Ranch dressing

Serves Makes 1 cup | Serves 6 (2 tablespoons – 40ml)

Seafood recipes

Seafood recipes

Seafood recipes

Find heart healthy seafood recipes...

Nutrition Evidence Summaries and Reviews

Nutrition Evidence Summaries and Reviews

Nutrition Evidence Summaries and Reviews

Chest x-ray for heart disease

Chest x-ray for heart disease

Chest x-ray for heart disease

This test can help your doctor determine if there is anything wrong with your heart....

Asian recipes

Asian recipes

Asian recipes

Find heart healthy Asian recipes....

Pregnancy and heart disease

Pregnancy and heart disease

Information and resources for health professionals....

How a pacemaker at 34 saved my life

How a pacemaker at 34 saved my life

How a pacemaker at 34 saved my life

Kim shares the emotional and physical upheaval experienced on her journey to diagnosis and recovery....

Heart failure clinical resources

Heart failure clinical resources

Resources and clinical information for health professionals...

Become a corporate partner

Become a corporate partner

Become a corporate partner

Partner with us to help us fight for Australian hearts....