I am
heartfoundation.org.au|Helpline 13 11 12

Creation of a Biological Pacemaker

Associate Professor Eddy Kizana, Institution: University of Sydney

2019 Vanguard Grant

Years funded: 2020-2021


Electronic pacemakers are the current standard of care for patients with symptomatic bradycardia. These devices require surgery for implantation, are prone to complications and their batteries become depleted. This project will advance the technologies required for biological pacing by gene therapy to the point of human application by the use of clinically relevant vectors and key-hole delivery approaches in a pre-clinical model of bradycardia.

Creation of biological pacemakers by gene transfer has progressed over the last 15 years from proof- of-principle to exciting pre-clinical studies. The seductive appeal of a focal gene injection converting quiescent heart muscle into a pacemaker has investigators world-wide feverishly working to achieve first-in-man status. The aims of this project are to achieve a safe, effective and durable biological pacemaker that has the unique prospect of supplementing and even possibly replacing electronic pacemakers. This project will lead to the development of tools and methods to overcome the barriers to clinical application of this technology including: methods for minimally invasive delivery of vectors for gene transfer and refinement of the vector for optimal biological pacemaker function.

The research team have created a sheep model of chronic heart block with implanted electronic pacemakers that will serve as an ideal model for testing biological pacemakers. The team and participating institutions make this project internationally competitive and within reach of clinical translation. Our host institute has a unique, clinical-grade, large animal cardiac catheter laboratory with federal regulatory body approvals to undertake the required experiments. Furthermore, we will be in a very strong position for transition to early- phase human studies via access to the NSW Office of Health and Medical Research-funded gene therapy vector production facility.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Heart Health Check Toolkit

Heart Health Check Toolkit

Give with Heart Day

Give with Heart Day

Give with Heart Day

Landmarks around Australia to turn red in support of the Heart Foundation’s Give with Heart Day...

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Give with Heart Day

Give with Heart Day

Give with Heart Day

Donate to Give with Heart Day by September 15 and every dollar you donate will be doubled*...

Research Directory

Research Directory

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Active Living NSW

Active Living NSW

Active Living NSW

Active Living NSW supports physical activity and healthy built environments in NSW ...

State based advocacy

State based advocacy

State based advocacy activity supporting local communities...

Returning to work after a heart attack

Returning to work after a heart attack

Returning to work after a heart attack

Discover how to plan for your return to work....

Mexican spice blend

Mexican spice blend

Mexican spice blend

Trek for Australian Hearts

Trek for Australian Hearts

Trek for Australian Hearts

Join the Heart Foundation in South Australia for the journey of a lifetime, trekking the ancient Flinders Ranges to help save Australian hearts....

What is an arrhythmia?

What is an arrhythmia?

What is an arrhythmia?

Arrhythmia is a fault in the heart’s electrical system, which affects your heart’s pumping rhythm....

Wholegrains and heart health

Wholegrains and heart health

Wholegrains and heart health

All you need to know about wholegrains to put you on the right track...

For professionals: Heart failure tools and resources

For professionals: Heart failure tools and resources

Resources for healthcare professionals on the management of patients with heart failure ...

Heart disease and pregnancy

Heart disease and pregnancy

Heart disease and pregnancy

Pregnancy is often referred to as the “ultimate stress test” for the body....

Keeping your heart healthy

Keeping your heart healthy

Keeping your heart healthy

Keeping your heart healthy is something you can work on every day. ...

Endorsement of externally developed clinical resources

Endorsement of externally developed clinical resources

Heart Week

Heart Week

Fats, oils and heart health

Fats, oils and heart health

Fats, oils and heart health

Get the right balance of healthy fats in your diet ...

Pilbara Aboriginal Heart Health Program

Pilbara Aboriginal Heart Health Program

Pilbara Aboriginal Heart Health Program

The program works with local communities to help improve heart health in the Pilbara....

The HEART Pitch – a research competition by NSW CVRN

The HEART Pitch – a research competition by NSW CVRN

Live event on Friday 17 September 2021 – get your elevator pitch ready for the NSW CVRN Rising Stars 3-Minute Research Competition....

Moroccan chickpea tagine

Moroccan chickpea tagine

25-40 minutes
Serves 4

Lipid management clinical information and resources

Lipid management clinical information and resources

Lipid management resources for health professionals...

Vegetarian lasagne

Vegetarian lasagne

Vegetarian lasagne

1 hour
Serves 6

24-hour Blood Pressure Monitoring

24-hour Blood Pressure Monitoring

Blood pressure monitoring at home using a 24-hour blood pressure monitor test....

WEBINAR | Absolute CVD risk assessment practical update

WEBINAR | Absolute CVD risk assessment practical update

A multidisciplinary panel of experts discuss the practical application of absolute CVD risk assessment through Heart Health Checks....

Aiming high after a stroke

Aiming high after a stroke

Aiming high after a stroke

Sami Kennedy-Sim is an Olympic freestyle skier specialising in Ski Cross. ...

Are you at risk of heart disease?

Are you at risk of heart disease?

Are you at risk of heart disease?

There is no single cause for any one heart condition, but there are risk factors that increase your chance of developing one. ...

WEBINAR | Heart Health Checks: the critical role of the practice nurse

WEBINAR | Heart Health Checks: the critical role of the practice nurse

WEBINAR | Heart Health Checks: the critical role of the practice nurse

This webinar discusses the role of practice nurses in conducting heart health checks...

Strawberry fields oats

Strawberry fields oats

Strawberry fields oats

10 minutes
Serves 2