I am
heartfoundation.org.au|Helpline 13 11 12

Colchicine and cognition in coronary artery disease

Dr Camilla Hoyos, Institution: University of Sydney

2018 Vanguard Grant

Years funded: 2019-2021


Cardiovascular disease is the earliest and strongest pathological marker for dementia, contributing to 30-50% of the risk. Oxidative stress and inflammation are thought to be key pathways by which cardiovascular disease may cause dementia. Previous intervention trials, treating traditional risk factors such as blood pressure, have targeted only older people (aged <70 years), arguably missing the opportunity for early intervention, since brain-related damage and cognitive decline are already established and unlikely to be reversible. Furthermore the majority of these studies have only assessed gross cognitive function, rather than sensitive measures of individual domains, which would miss early and subtle, yet clinically relevant, changes. This proposed study will assess cognition and brain integrity in participants aged 40-65 with established coronary artery disease who are enrolled in an ongoing randomised-controlled trial of an anti-inflammatory medication. This will be the first ever study to investigate brain outcomes of this anti-inflammatory medication.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Research Directory

Research Directory

Heart Health Check Toolkit

Heart Health Check Toolkit

Absolute CVD risk assessment resources

Absolute CVD risk assessment resources

Resources and clinical information for health professionals...

Q&A with Professor Kerry-Anne Rye

Q&A with Professor Kerry-Anne Rye

Q&A with Professor Kerry-Anne Rye

A new way to keep people who have had a heart attack healthy...

Seafood recipes

Seafood recipes

Seafood recipes

Find heart healthy seafood recipes...

Our corporate partners

Our corporate partners

Our corporate partners

We value the support of all of our corporate partners....

Strategic Grants

Strategic Grants

Strategic Grants aim to generate innovative and collaborative research in the areas of identified knowledge gaps or those deemed to be priorities of the Heart Foundation. ...

Action Plans

Action Plans

Action Plans

Recovery is a long journey, so having a plan makes a huge difference. Using an action plan gives you a step-by-step guide to improving your lifestyle....

For professionals: Heart Health Checks

For professionals: Heart Health Checks

Heart Health Checks have been supported by Medicare since April 2019....

Heart Foundation recipes

Heart Foundation recipes

Heart Foundation recipes

Check out our recipe categories to find your next heart healthy meal....

Why are you playing this game? It’s putting your heart at risk.

Why are you playing this game? It’s putting your heart at risk.

Why are you playing this game? It’s putting your heart at risk.

The game is “hide and seek”. You play it without even realising. The shock is that when you play this game, you could be placing your heart health at risk....

Hypertension clinical information and guidelines

Hypertension clinical information and guidelines

Clinical information for diagnosis and management of hypertension....

Chicken recipes

Chicken recipes

Chicken recipes

Find heart healthy chicken recipes....

Fundraise to save Australian hearts

Fundraise to save Australian hearts

Fundraise to save Australian hearts

Join our community of fundraisers who are committed to taking action to fight heart disease....

Nutrition Resources for Practice and Patient Care

Nutrition Resources for Practice and Patient Care

Nutrition Resources for Practice and Patient Care

Heart disease and pregnancy

Heart disease and pregnancy

Heart disease and pregnancy

Pregnancy is often referred to as the “ultimate stress test” for the body....

Our research stories

Our research stories

Our research stories

We fund amazing researchers who have important stories to tell...

Heart Age Calculator

Heart Age Calculator

Heart Age Calculator

Could you be at risk of heart disease? Get your estimated heart age now....

For Professionals: COVID-19 & cardiovascular disease

For Professionals: COVID-19 & cardiovascular disease

For Professionals: COVID-19 & cardiovascular disease

Information and resources for health care professionals....

Create your fundraiser at Do it for Heart

Create your fundraiser at Do it for Heart

Create your fundraiser at Do it for Heart

Become a Heart Foundation fundraiser, do it for heart and make a real difference to your community....

Fruit and nut muesli

Fruit and nut muesli

Fruit and nut muesli

Beef recipes

Beef recipes

Beef recipes

Find heart healthy beef recipes....

Driving Best Practice CVD Prevention in a Post-COVID World

Driving Best Practice CVD Prevention in a Post-COVID World

Driving Best Practice CVD Prevention in a Post-COVID World

Heart conditions in women

Heart conditions in women

Heart conditions in women

Like men, women can be diagnosed with a range of heart conditions....

How your heart works

How your heart works

How your heart works

Your heart is a muscle that pumps blood to all parts of your body. The blood gives your body the oxygen and nourishment it needs to work properly. ...

Celebrate the life of someone you love by giving to the Heart Foundation in their memory

Celebrate the life of someone you love by giving to the Heart Foundation in their memory

Celebrate the life of someone you love by giving to the Heart Foundation in their memory

Ranch dressing

Ranch dressing

Ranch dressing

Serves Makes 1 cup | Serves 6 (2 tablespoons – 40ml)

Blood tests for heart disease

Blood tests for heart disease

Blood tests can measure the levels of substances such as blood fat to show if, and how much of, your heart has been damaged....