I am
Cardiovascular Dysfunction in Advanced Liver Disease and After Liver Transplantation
heartfoundation.org.au|Helpline 13 11 12

Cardiovascular Dysfunction in Advanced Liver Disease and After Liver Transplantation

Dr Anoop Koshy, Institution: University of Melbourne

2017 Health Professional Scholarship

Years funded: 2018-2021


Liver disease affects at least 20% of the Australian population. Liver transplantation (LT) is the only curative treatment option for patients with life-threatening liver disease.

It is well recognised that cardiovascular disease is one of the leading causes or morbidity and mortality in patients after LT.

The scarcity of donor organs means that LT is a limited and valuable resource. Therefore, potential transplant candidates undergo detailed cardiac assessment prior to LT to exclude those with significant underlying cardiovascular disease.

This study will examine a new approach to improve detection and early treatment of heart disease in LT candidates. It integrates screening with CT imaging of coronary arteries and an assessment of heart function with stress testing.

Follow-up CT imaging of heart arteries will be performed to assess if LT itself predisposes patients to rapid progression of coronary heart disease.

Patients with advanced liver disease can also have structural changes in the heart that predispose them to heart failure before and after LT.

This study aims to further investigate this phenomenon called 'cirrhotic cardiomyopathy' with serial heart ultrasound scans.

The cardiac effects of a medication called terlipressin, used in patients with advanced liver disease, will additionally be studied with the expectation that it may play a role in reversing this syndrome.

This project is co-funded with NHMRC - National Health and Medical Research Council.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Research Directory

Research Directory

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Heart Health Check Toolkit

Heart Health Check Toolkit

Tasty recipes to start the day | Breakfast Recipe Booklet

Tasty recipes to start the day | Breakfast Recipe Booklet

Tasty recipes to start the day | Breakfast Recipe Booklet

Have an easy and delicious start to your day. Get your free copy now....

Heart attack recovery – your first month

Heart attack recovery – your first month

Heart attack recovery – your first month

Explore the Heart Foundation’s guide on what to expect in the first month after your heart attack. ...

Key healthy eating messages for heart attack recovery 

Key healthy eating messages for heart attack recovery 

Key healthy eating messages for heart attack recovery 

Eating healthy foods can help you recover and reduce your risk of more heart problems. ...

WEBINAR | The future of CVD risk assessment

WEBINAR | The future of CVD risk assessment

WEBINAR | The future of CVD risk assessment

Should population-based CVD risk assessment models make way for individualised risk prediction techniques?...

Coronary Artery Calcium Scoring

Coronary Artery Calcium Scoring

A coronary artery calcium score can be used following a Heart Health Check to estimate your risk of heart attack....

Italian recipes

Italian recipes

Italian recipes

Find heart healthy Italian recipes....

How we fought heart disease in 2020

How we fought heart disease in 2020

How we fought heart disease in 2020

Everything we do is possible thanks to the generosity of our supporters. ...

Templates integrated in Best Practice software

Templates integrated in Best Practice software

Popular Heart Health Check templates – CVD risk assessment and management plan – are directly accessible from within Bp Premier ...

Permanent Pacemaker (PPM)

Permanent Pacemaker (PPM)

A small, battery-powered device that is fitted under the skin of your upper chest....

Loaded veggie shepherds pie

Loaded veggie shepherds pie

Loaded veggie shepherds pie

1 hour
Serves Serves 4 (as a main meal)

Supporting local Councils in South Australia

Supporting local Councils in South Australia

Supporting local Councils in South Australia

Resources to help support your council region to be healthy, connected and safe....

Spontaneous Coronary Artery Dissection (SCAD)

Spontaneous Coronary Artery Dissection (SCAD)

Clinical information and links to SCAD resources....

Types of physical activity

Types of physical activity

Types of physical activity

Nine out of 10 Australians could reduce the risk of heart disease by walking as little as 15 minutes more each day....

Heart conditions in women

Heart conditions in women

Heart conditions in women

Like men, women can be diagnosed with a range of heart conditions....

Heart Bypass Surgery

Heart Bypass Surgery

Coronary bypass surgery is a common procedure that can dramatically improve the health of your heart. ...

Chest x-ray for heart disease

Chest x-ray for heart disease

Chest x-ray for heart disease

This test can help your doctor determine if there is anything wrong with your heart....

Cardiovascular disease (CVD) risk assessment and management

Cardiovascular disease (CVD) risk assessment and management

Absolute CVD risk assessment is an integrated approach that estimates the cumulative risk of multiple risk factors to predict a heart attack or stroke event in the next five years....

Mental health and heart disease

Mental health and heart disease

Mental health and heart disease

Having a mental health condition can have a negative impact on your heart health and increase your risk of heart disease....

Breakfast bean and mushroom pizza

Breakfast bean and mushroom pizza

Breakfast bean and mushroom pizza

20 minutes
Serves 2

Mighty mango smoothie

Mighty mango smoothie

Mighty mango smoothie

Dinner recipes

Dinner recipes

Dinner recipes

Search our heart healthy dinner recipes for tonights main meal...

Moroccan chickpea tagine

Moroccan chickpea tagine

25-40 minutes
Serves 4

Our supporters 

Our supporters 

Our supporters 

Working together to save Australian hearts...

Fats, oils and heart health

Fats, oils and heart health

Fats, oils and heart health

Get the right balance of healthy fats in your diet ...

Q&A with Professor Levon Khachigian

Q&A with Professor Levon Khachigian

Q&A with Professor Levon Khachigian

Developing a new medicine for inflammatory cardiovascular disease...

Wholegrains and heart health

Wholegrains and heart health

Wholegrains and heart health

All you need to know about wholegrains to put you on the right track...