I am
heartfoundation.org.au|Helpline 13 11 12

Can inflammation predict adverse cardiovascular events in the population

Associate Professor Frank Sanfilippo, Institution: University of Western Australia

2018 Vanguard Grant

Years funded: 2019-2020


Inflammation is recognised as an important process in people with heart disease and may lead to a higher risk of heart attack. There are several trials in progress around the world looking at this issue and testing old and new medications that treat inflammation. However, at present there are no tests that can reliably measure this inflammatory response in order to identify who should receive these treatments or for monitoring the treatment. We have developed such a test. By including data on inflammation in addition to well-known risk factors such as cholesterol level and smoking, we aim to increase the ability to predict cardiovascular events in people with no history of cardiovascular disease.

Our plan is to use existing data from 2385 people in the Busselton area in WA in 1994/95 that includes all the common risk factors for heart disease, and add test results of novel biomarkers of inflammation. From this, we will be able to tell if people with higher levels of inflammation are more likely to develop heart disease over the 20 years of follow-up, and assess how this increased risk relates to inflammation and the common risk factors. We can then identify people who may benefit the most from the treatments being trailed, thus improving our ability to monitor and treat heart disease in the population, and ultimately lower the risk of heart attacks and death. Inflammation may also prove beneficial in predicting risk in people who have had a heart attack and we can test this in a subsequent study.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Heart Health Check Toolkit

Heart Health Check Toolkit

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Give with Heart Day

Give with Heart Day

Give with Heart Day

Landmarks around Australia to turn red in support of the Heart Foundation’s Give with Heart Day...

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Research Directory

Research Directory

Give with Heart Day

Give with Heart Day

Give with Heart Day

Donate to Give with Heart Day by September 15 and every dollar you donate will be doubled*...

Spontaneous Coronary Artery Dissection (SCAD)

Spontaneous Coronary Artery Dissection (SCAD)

Clinical information and links to SCAD resources....

2020 Strategic Grant Recipients

2020 Strategic Grant Recipients

Our Annual Reports

Our Annual Reports

Our Annual Reports

Discover our Annual reports from 2013 onwards. ...

For professionals: Cardiovascular disease risk assessment for Aboriginal and Torres Strait Islander peoples 

For professionals: Cardiovascular disease risk assessment for Aboriginal and Torres Strait Islander peoples 

Recommendations for assessing Cardiovascular disease (CVD) risk in Aboriginal and Torres Strait Islander peoples ...

Vegetarian recipes

Vegetarian recipes

Vegetarian recipes

Search through our vegetarian recipes...

Become a corporate partner

Become a corporate partner

Become a corporate partner

Partner with us to help us fight for Australian hearts....

Supporting Your Emotional Wellbeing: An Online Forum for Young Heart Patients

Supporting Your Emotional Wellbeing: An Online Forum for Young Heart Patients

Supporting Your Emotional Wellbeing: An Online Forum for Young Heart Patients

Healthy Active by Design

Healthy Active by Design

Healthy Active by Design

Improving the design of our cities, towns, streets and buildings makes it easier for Australians to lead heart-healthy lives....

What is a heart attack?

What is a heart attack?

What is a heart attack?

The most common cause of a heart attack is coronary heart disease....

For professionals: Heart failure tools and resources

For professionals: Heart failure tools and resources

Resources for healthcare professionals on the management of patients with heart failure ...

Mighty mango smoothie

Mighty mango smoothie

Mighty mango smoothie

Find a cardiac rehabilitation service near you

Find a cardiac rehabilitation service near you

This cardiac services directory presents information on cardiac rehab programs offered across Australia....

What is an arrhythmia?

What is an arrhythmia?

What is an arrhythmia?

Arrhythmia is a fault in the heart’s electrical system, which affects your heart’s pumping rhythm....

Donate to the Heart Foundation

Donate to the Heart Foundation

Donate to the Heart Foundation

Every dollar that you donate will help fund research, support and programs that help save lives....

For professionals: Guidelines for acute rheumatic fever and rheumatic heart disease

For professionals: Guidelines for acute rheumatic fever and rheumatic heart disease

Australian  guidelines  for  prevention, diagnosis and  management of  acute  rheumatic  fever and  rheumatic  heart  disease ...

Christmas recipes

Christmas recipes

Christmas recipes

Find heart healthy festive recipes. ...

Driving and travelling after a heart attack

Driving and travelling after a heart attack

Driving and travelling after a heart attack

Explore our guide for driving and heart attack recovery. ...

Cardiac Rehabilitation Advocacy

Cardiac Rehabilitation Advocacy

Heart health information in your language

Heart health information in your language

A selection of heart health information brochures in a range languages...

WEBINAR | Absolute CVD risk assessment practical update

WEBINAR | Absolute CVD risk assessment practical update

A multidisciplinary panel of experts discuss the practical application of absolute CVD risk assessment through Heart Health Checks....

WEBINAR | Navigating the latest updates on CVD prevention

WEBINAR | Navigating the latest updates on CVD prevention

Asian (Chilli, soy and sesame) dressing

Asian (Chilli, soy and sesame) dressing

Asian (Chilli, soy and sesame) dressing

COVID-19 info & FAQs

COVID-19 info & FAQs

COVID-19 info & FAQs

Information and FAQs about COVID-19 and heart disease....

Absolute CVD risk clinical guidelines

Absolute CVD risk clinical guidelines

The Absolute Cardiovascular Disease Risk (CVD) Guidelines helps healthcare professionals identify, prevent and manage a person's risk of developing CVD. ...