I am
Bench-to-bedside approach to improving management and outcomes for patients with heart failure
heartfoundation.org.au|Helpline 13 11 12

Bench-to-bedside approach to improving management and outcomes for patients with heart failure

Associate Professor Aaron Sverdlov, Institution: The University of Newcastle

2017 Future Leader Fellowship

Years funded: 2018-2021


Heart failure (HF) is the commonest and most disabling form of chronic cardiovascular disease with up to half of patients having the specific problem of heart muscle relaxation.

There is no effective therapy for this type of heart failure. Statistically, HF patients are three times more likely to die within three years than those diagnosed with cancer.

The burden of HF is rapidly increasing due to increased prevalence of diabetes, obesity and metabolic syndrome.

With an overall aim of improving management and outcomes for patients with heart failure, Associate Professor Aaron Sverdlov’s research program has 3 interrelated themes:

1. BETTER UNDERSTANDING OF MECHANISMS UNDERLYING HEART FAILURE DUE TO OBESITY: We will dissect whether a modification of proteins in energy centres of the cells are responsible for heart dysfunction in HF.

Outcomes: better understanding of mechanisms involved. This can lead to development of new targeted therapies for this form of heart failure, which does not have any effective therapies.

2. NOVEL BIOMARKERS FOR EARLY DETECTION OF CARDIAC ABNORMALITIES: Associate Professor Sverdlov has described a novel biomarker for heart thickening and scarring (FSTL3). He will examine its prognostic utility in 1) patients with obesity and 2) patients undergoing chemotherapy that is toxic to the heart.


Outcomes: As early diagnosis and treatment are the cornerstone of improved health outcomes, FSTL3 may be a valuable tool for doctors to detect heart abnormalities early and initiate preventative treatment

3. INTENSIVE WEIGHT LOSS PROGRAM TO IMPROVE OUTCOMES IN HEART FAILURE PATIENTS. We will investigate if intensive weight loss program as part of heart failure service improves patient outcomes including hospitalizations, cardiac function, and quality of life.

Outcomes: improved weight loss and hence heart function in reginal and rural heart failure patients.

You might also be interested in

Research Directory

Research Directory

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Optimizing stroke therapy - advanced brain imaging and rapid restoration of blood flow to the brain

Professor Bruce Campbell, Institution: University of Melbourne...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Strategies to optimise cardio-metabolic health

Strategies to optimise cardio-metabolic health

Associate Professor Melinda Carrington, Institution: Baker Heart and Diabetes Institute...

Heart Health Check Toolkit

Heart Health Check Toolkit

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne...

Research Directory

Research Directory

MyMarathon

MyMarathon

MyMarathon

The fundraising race where you set the pace. Run, jog or walk MyMarathon at your own pace during October....

Give with Heart Day

Give with Heart Day

Give with Heart Day

Donate to Give with Heart Day by September 15 and every dollar you donate will be doubled*...

Give with Heart Day

Give with Heart Day

Give with Heart Day

Landmarks around Australia to turn red in support of the Heart Foundation’s Give with Heart Day...

Heart conditions in women

Heart conditions in women

Heart conditions in women

Like men, women can be diagnosed with a range of heart conditions....

Sorting out your finances after a heart attack

Sorting out your finances after a heart attack

Sorting out your finances after a heart attack

Explore how to manage your financial concerns after a heart attack. ...

Kids recipes

Kids recipes

Kids recipes

Find heart healthy kids recipes...

Dinner recipes

Dinner recipes

Dinner recipes

Search our heart healthy dinner recipes for tonights main meal...

Is salt bad for your heart?

Is salt bad for your heart?

Is salt bad for your heart?

Most Australians are eating more than the recommended amounts and this can cause health problems....

Christmas recipes

Christmas recipes

Christmas recipes

Find heart healthy festive recipes. ...

Blood cholesterol

Blood cholesterol

Blood cholesterol

Keeping your blood cholesterol at a healthy level can help you reduce your risk of heart disease and other serious conditions. ...

Aboriginal heart health

Aboriginal heart health

Aboriginal heart health

Visit the St Vincents Hospital NSW and Heart Foundation Aboriginal heart health website for more information...

Cardiovascular disease (CVD) risk assessment and management

Cardiovascular disease (CVD) risk assessment and management

Absolute CVD risk assessment is an integrated approach that estimates the cumulative risk of multiple risk factors to predict a heart attack or stroke event in the next five years....

For professionals: Cardiovascular disease risk assessment for Aboriginal and Torres Strait Islander peoples 

For professionals: Cardiovascular disease risk assessment for Aboriginal and Torres Strait Islander peoples 

Recommendations for assessing Cardiovascular disease (CVD) risk in Aboriginal and Torres Strait Islander peoples ...

Permanent Pacemaker (PPM)

Permanent Pacemaker (PPM)

A small, battery-powered device that is fitted under the skin of your upper chest....

Keeping a close watch on brain and kidney health during heart surgery.

Keeping a close watch on brain and kidney health during heart surgery.

Keeping a close watch on brain and kidney health during heart surgery.

Philanthropic investments

Philanthropic investments

Philanthropic investments

Making philanthropic investments through the Heart Foundation can transform Australians’ health. ...

What is heart failure?

What is heart failure?

What is heart failure?

Heart failure is a condition where your heart isn’t pumping as well as it should be....

Our programs and initiatives

Our programs and initiatives

Our programs and initiatives

The Heart Foundation delivers innovative, evidence-based programs and initiatives to support and prevent heart disease in Australia...

Moroccan chickpea tagine

Moroccan chickpea tagine

25-40 minutes
Serves 4

Women and heart disease

Women and heart disease

Women and heart disease

Every day, 22 women lose their lives to this condition....

Seafood recipes

Seafood recipes

Seafood recipes

Find heart healthy seafood recipes...

Key healthy eating messages for heart attack recovery 

Key healthy eating messages for heart attack recovery 

Key healthy eating messages for heart attack recovery 

Eating healthy foods can help you recover and reduce your risk of more heart problems. ...

Beef recipes

Beef recipes

Beef recipes

Find heart healthy beef recipes....

What is a cardiac arrest?

What is a cardiac arrest?

What is a cardiac arrest?

With immediate help a cardiac arrest can be survived. Learn how to save a life....

Being a carer for a heart attack patient

Being a carer for a heart attack patient

Being a carer for a heart attack patient

Your role as a carer for a heart attack patient is an important one – explore some useful things to know....

Supporting Your Emotional Wellbeing: An Online Forum for Young Heart Patients

Supporting Your Emotional Wellbeing: An Online Forum for Young Heart Patients

Supporting Your Emotional Wellbeing: An Online Forum for Young Heart Patients

WEBINAR | Lipids in the limelight: clinical update on screening and management

WEBINAR | Lipids in the limelight: clinical update on screening and management